Results 91 to 100 of about 9,738,209 (281)

Good Practice Report : Curriculum Renewal [PDF]

, 2011
This good practice report, commissioned by the ALTC, provides a summative evaluation of useful outcomes and good practices from ALTC projects and fellowships on curriculum renewal.
Narayan, Bhuva, Edwards, Sylvia L., Narayan, B, Edwards, SL   +3 more
core   +1 more source

Guide to REgional Good Practice eHealth

, 2007
This report shows the result of the work of IANIS+ eHealth work group (WG). The WG has collected regional eHealth experiences from around Europe through a number of activities: • Regional eHealth case studies of which 17 (from 15 regions) are shown in ...
Bai, Guohua, Malmqvist, Gustav
core   +2 more sources

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Good Practice in Action Fact Sheet 120

, 2021
This practitioner factsheet looks at the factors that counsellors and psychotherapists need to keep in mind when working with clients who present at risk.
Reeves, Andrew
core   +1 more source

Good Manufacturing Practice for ATMPs

EuroGCT website: https://www.eurogct.org/research-pathways/manufacturing/good-manufacturing-practiceUnder European Union (EU) law, the manufacture or import of medicinal products in the European Union is subject to manufacturing or import authorisation ...
Gilbert, Luc-Sylvain, Mahalatchimy, Aurélie   +1 more
core   +1 more source

GMP-manufactured CRISPR/Cas9 technology as an advantageous tool to support cancer immunotherapy

Journal of Experimental & Clinical Cancer Research
Background CRISPR/Cas9 system to treat human-related diseases has achieved significant results and, even if its potential application in cancer research is improving, the application of this approach in clinical practice is still a nascent technology ...
M Caforio, S Iacovelli, C Quintarelli, F Locatelli, Valentina Folgiero   +4 more
doaj   +1 more source

Good Manufacturing Practice-Compliant Production and Lot-Release of Ex Vivo Expanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders

Frontiers in Immunology, 2017
In recent years, the exploration of regulatory T cell (Treg)-based cellular therapy has become an attractive strategy to ameliorate inflammation and autoimmunity in various clinical settings. The main obstacle to the clinical application of Treg in human
Manuel Wiesinger, Diane Stoica, Susanne Roessner, Carmen Lorenz, Anika Fischer, Raja Atreya, Clemens F. Neufert, Imke Atreya, Alexander Scheffold, Beatrice Schuler-Thurner, Markus F. Neurath, Gerold Schuler, Caroline J. Voskens   +12 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Helping Underdeveloped Lungs with Cells (HULC-2): mesenchymal stromal cells in extreme preterm infants at risk of developing bronchopulmonary dysplasia – a study protocol of a phase 2 multicentre double blind randomised controlled trial in Canada

BMJ Open
Introduction Bronchopulmonary dysplasia (BPD) remains a major complication among extremely low gestational age (ELGA) infants, with long-term respiratory and neurodevelopmental consequences.
Dean A Fergusson, Saad Khan, Mario Rüdiger, Emanuela Ferretti, Laurent Renesme, Bernard Thébaud, Chantal Horth, Rebecca Grimwood, Liam Da Sylva, Viviane Olson, Chanele Cyr-Depauw, Daniel Freund, Marius A Möbius, Samantha Hodgins, David Courtman   +14 more
doaj   +1 more source