Results 71 to 80 of about 310,473 (292)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A Comparative Study of Beauty and its Relation to Pleasure and Goodness in the Philosophy of Plotinus and Avicenna [PDF]
آموزههای فلسفه اسلاميThe truth and nature of beauty, as a secondary intelligible (Arabic: مَعْقولُ الْثَّانی, romanized: maʿqūl al-thānī), have become a topic of discussion among philosophers.
Muḥammūd Ṣeydiī +1 more
doaj +1 more source
Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence
Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari +9 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Climate Change and Virtue: An Apologetic
Humanities, 2014 The prominent Australian earth scientist, Tim Flannery, closes his recent book Here on Earth: A New Beginning with the words “… if we do not strive to love one another, and to love our planet as much as we love ourselves, then no further progress is ...
Mike Hulme
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Calling as a Motivating Factor of the Development of Education in Ukraine
Філософія освіти, 2017 The article raises importance of the topic of mission in contemporary philosophy and educational sciences. Mission is a basic idea for building up of civil society as a community of responsible and committed people. Mission has a special significance for
Yevhen Ivanovych Muliarchuk
doaj +1 more source
R2ucare: An R package to perform goodness-of-fit tests for capture-recapture models
bioRxiv, 2017 Assessing the quality of fit of a statistical model to data is a necessary step for conducting safe inference. We introduce R2ucare, an R package to perform goodness-of-fit tests for open single- and multi-state capture-recapture models. R2ucare also has
O. Gimenez +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Reading The Silence In The Maternal Text Of Carol Shields’ Unless
Gender Studies, 2014 This article scrutinizes the representation of silence in Carol Shields’ novel Unless. It analyses the problematic behind the mother-daughter relationship between Reta Winters and her daughter Norah by applying the theories of Cixous, Kristeva, Chodorow ...
İNCEOĞLU ŞEYDA
doaj +1 more source