Results 51 to 60 of about 575,729 (287)
Goodness-of-Fit Tests in Nonparametric Regression [PDF]
SSRN Electronic Journal, 2006 AMS classifications: 62G08, 62G10, 62G20, 62G30; 60F17.
Einmahl, J.H.J., Keilegom, I. van
openaire +8 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
On Entropy Test for Conditionally Heteroscedastic Location-Scale Time Series Models
Entropy, 2017 This study considers the goodness of fit test for a class of conditionally heteroscedastic location-scale time series models. For this task, we develop an entropy-type goodness of fit test based on residuals.
Sangyeol Lee, Minjo Kim
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Frontiers in Psychology, 2018 The performance of the limited-information statistic M2 for diagnostic classification models (DCMs) is under-investigated in the current literature. Specifically, the investigations of M2 for specific DCMs rather than general modeling frameworks are ...
Fu Chen, Yanlou Liu, Tao Xin, Ying Cui
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
New L2-type exponentiality tests [PDF]
, 2019 We introduce new consistent and scale-free goodness-of-fit tests for the exponential distribution based on the Puri-Rubin characterization. For the construction of test statistics we employ weighted L2 distance between V-empirical Laplace transforms of ...
Cuparić, Marija +2 more
core
On APF Test for Poisson Process with Shift and Scale Parameters
, 2018 We propose the goodness of fit test for inhomogeneous Poisson processes with unknown scale and shift parameters. A test statistic of Cramer-von Mises type is proposed and its asymptotic behavior is studied.
Dabye, A. S. +2 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source