Results 141 to 150 of about 81,484 (272)
Journal of Diabetes Investigation, EarlyView.In this target trial emulation of patients with immune‐mediated inflammatory diseases and type 2 diabetes, SGLT2 inhibitor initiation was not associated with a clear increase in UTI risk versus metformin, including across immunosuppressive therapy strata.
Hiroshi Tsushima +6 more
wiley +1 more source
Atypical musculoskeletal manifestations of gout in hyperuricemia patients
, 2019 Muhammad Sakti, Muhammad Andry Usman, Jansen Lee, Michael Benjamin, Qariah Maulidiah Department of Orthopaedic and Traumatology, Hasanuddin University Teaching Hospital, Makassar, Indonesia Abstract: Deposition of tophus is a common feature in chronic ...
Maulidiah Q +4 more
core
Neuregulin 4‐dependent MAPK amplification mediates urate‐induced β‐cell dysfunction
Journal of Diabetes Investigation, EarlyView.Hyperuricemia impairs glucose homeostasis by inducing pancreatic β‐cell apoptosis without insulin resistance. In male Uox‐KO mice, urate upregulates Nrg4, which amplifies MAPK signaling and drives β‐cell death. Thus, hyperuricemia disrupts glucose metabolism via the Nrg4‐MAPK axis.
Yunyang Wang +7 more
wiley +1 more source
The association between thyroid disorders and incident gout: population-based case–control study
, 2017 Saskia G Bruderer,1,2 Christoph R Meier,1–3 Susan S Jick,3 Michael Bodmer1,4 1Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, 2Hospital Pharmacy ...
Meier CR, Bruderer SG, Bodmer M, Jick SS
core
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background Restrictive transfusion (Hb < 7 g/dL) is recommended for most perioperative patients, but the optimal threshold for those with cardiovascular disease or Hb 7–10 g/dL remains uncertain. The Perioperative Transfusion Trigger Score (POTTS), which integrates adrenaline requirement, FiO2, temperature, and angina history, may standardize ...
Shucong Liang +9 more
wiley +1 more source
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Objective To estimate the risk for oral squamous cell carcinoma (OSCC) among patients with oral lichen planus (OLP) or lichenoid lesions (OLL) and the possible risk factors. Material and Methods Two hundred thirty‐nine OLP and 84 OLL patients diagnosed between years 1982 and 2017 were followed up to December 2023, diagnosis of an OSCC, or ...
Mari Vehviläinen +3 more
wiley +1 more source
Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases
Journal of Periodontal Research, EarlyView.This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini +3 more
wiley +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT Sleep is increasingly understood as a socially embedded phenomenon. This study examined how structural and functional aspects of social support, as well as loneliness, relate to sleep health in a German sample of middle‐aged adults (N = 5388).
Eva De Camargo +9 more
wiley +1 more source