Results 151 to 160 of about 139,634 (224)

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma

The Journal of Physiology, EarlyView.
Abstract figure legend PANX1 and PANX3 show opposite expression patterns in patient‐derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. Within the tumour PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour ...
Brooke L. O'Donnell, Danielle Johnston, Ayushi Bhatt, Zahra Kardan, Dan Stefan, Andrew Bysice, Samar Sayedyahossein, Lina Dagnino, Matthew Cecchini, Sampath Kumar Loganathan, Kathryn Roth, Silvia Penuela   +11 more
wiley   +1 more source

An effective encoding of human medical conditions in disease space provides a versatile framework for deciphering disease associations

Quantitative Biology, Volume 13, Issue 3, September 2025.
Abstract It is challenging to identify comorbidity patterns and mechanistically investigate disease associations based on health‐related data that are often sparse, large‐scale, and multimodal. Adopting a systems biology approach, embedding‐based algorithms provide a new perspective to examine diseases under a unified framework by mapping diseases into
Tianxin Xu, Yu Li, Xin Gao, Andrey Rzhetsky, Gengjie Jia   +4 more
wiley   +1 more source

Gout and Patellar Tendon Tears: An Uncommon Intersection. [PDF]

Cureus
Aurangzeb A, Tan Wei Shen V, Sirisena D.
europepmc   +1 more source

“It's Just Good Science”: A Qualitative Study Exploring Equity, Diversity, and Inclusion in Canadian Arthritis Research

Arthritis Care &Research, Volume 77, Issue 6, Page 801-810, June 2025.
Objective Despite knowledge that health outcomes vary according to patient characteristics, identity, and geography, including underrepresented populations in arthritis research remains a challenge. We conducted interviews to explore how researchers in arthritis have used equity, diversity, and inclusion (EDI) principles to inform their research ...
Megan M. Thomas, Mark Harrison, Cheryl Barnabe, Charlene E. Ronquillo, J. Antonio Avina‐Zubieta, Anna Samson, Michael Kuluva, Natasha Trehan, Mary A. De Vera   +8 more
wiley   +1 more source

Delineating circulating lymphocyte subsets in the transition from gout remission to recurrence. [PDF]

Front Immunol
Yu H, Wang L, Qin L, Yu H, Hu R, Jia Z, Bao H, Wang H, Xue W, Song Y, Yin Z, Peng A.   +11 more
europepmc   +1 more source

Relationship Between Gout Flare States and Patient‐Reported Outcomes After Allopurinol Initiation

Arthritis Care &Research, Volume 77, Issue 6, Page 727-731, June 2025.
Objective Gout flares are the most important clinical feature of the disease. A hypothetical maximum flare occurrence in the preceding six months has been suggested to be no flares for a patient‐acceptable symptom state (PASS) and only one flare for low disease activity (LDA).
Lisa K. Stamp, Chris Frampton, Sarah Stewart, Keith J. Petrie, N. Lawrence Edwards, Angelo Gaffo, Nicola Dalbeth   +6 more
wiley   +1 more source

Exploring Therapeutic Potential of Bi-Qi Capsules in Treatment of Gout by Discovering Crucial Drug Targets. [PDF]

Pharmaceuticals (Basel)
Xie J, Zhang Y, Ren R, Bu R, Chen L, Hou J, Shang D, Liu Y, Wang D, Wang T, Zhou H.   +10 more
europepmc   +1 more source

Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Daphnetin, a coumarin derivative, regulates the AMPK/mTOR signaling pathway to inhibit inflammation and promote autophagy in monosodium urate‐induced mice and THP‐1 cells, thereby suppressing MSU‐induced gouty arthritis. Abstract Gouty arthritis (GA) is an inflammatory disease resulting from monosodium urate (MSU) crystal deposition in joints and ...
Zhiyong Liu, Aichun Chu, Zhiqian Bai, Chao Yang   +3 more
wiley   +1 more source

Pacific community's perceptions on how to improve uptake of urate-lowering therapy for Pacific gout patients. [PDF]

Int J Equity Health
Ofanoa S, Ofanoa M, Tu'akoi S, Lutui H, Heather M, Goodyear-Smith F.   +5 more
europepmc   +1 more source

Use of Sodium‐Glucose Transport Protein 2 Inhibitors and the Incidence of Urolithiasis: A Multi‐Database and Cross‐Country Study in Patients With Type 2 Diabetes Mellitus

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1775-1783, June 2025.
The benefits of sodium‐glucose transport protein 2 inhibitor (SGLT2i) use on severe urolithiasis requiring surgery remains unclear. All patients with incident T2D in Taiwan National Health Institution databases (2016–2021) and TriNetX datasets (2014–2023) were retrospectively analyzed.
Mu‐Chi Chung, Chia‐Yen Lin, Chao‐Hsiang Chang, Yi‐Huei Chang, Po‐Jen Hsiao, Chi‐Shun Lien, Laing‐You Wu, Ming‐Ju Wu, Jeng‐Jer Shieh, Peir‐Haur Hung, Hsin‐Hua Chen, Chi‐Jung Chung   +11 more
wiley   +1 more source