Results 11 to 20 of about 62,613 (212)

siRNA‐based nanotherapeutics as emerging modalities for immune‐mediated diseases: A preliminary review

Cell Biology International, Volume 46, Issue 9, Page 1320-1344, September 2022., 2022
Abstract Immune‐mediated diseases (IMDs) are chronic conditions that have an immune‐mediated etiology. Clinically, these diseases appear to be unrelated, but pathogenic pathways have been shown to connect them. While inflammation is a common occurrence in the body, it may either stimulate a favorable immune response to protect against harmful signals ...
Saman Sargazi, Rabia Arshad, Reza Ghamari, Abbas Rahdar, Ali Bakhshi, Sonia Fathi Karkan, Narges Ajalli, Muhammad Bilal, Ana M. Díez‐Pascual   +8 more
wiley   +1 more source

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways [PDF]

International Journal of Molecular Sciences, 2019
Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB and NLRP3 signaling pathways, lie at the core of gout. This study aimed to evaluate the antigout effect of Cichorium intybus L. (also known as chicory) in vivo and in vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections.
Yu Wang, Zhijian Lin, Bing Zhang, Zhuoxi Jiang, Fanfan Guo, Ting Yang   +5 more
openaire   +2 more sources

Effect of renal impairment on the pharmacokinetics and safety of dorzagliatin, a novel dual‐acting glucokinase activator

Clinical and Translational Science, Volume 15, Issue 2, Page 548-557, February 2022., 2022
Abstract Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI) on dorzagliatin’s pharmacokinetics (PKs) and safety, and to guide appropriate clinical ...
Jia Miao, Ping Fu, Shuang Ren, Chao Hu, Ying Wang, Chengfeng Jiao, Ping Li, Yu zhao, Cui Tang, Yuli Qian, Rong Yang, Yanli Dong, Jing Rong, Yaohui Wang, Xiaowei Jin, Yu Sun, Li Chen   +16 more
wiley   +1 more source

Effectiveness of medication withdrawal in older fallers: Results from the improving medication prescribing to reduce risk of falls (IMPROveFALL) trial [PDF]

, 2017
Objectives: to investigate the effect of withdrawal of fall-risk-increasing-drugs (FRIDs) versus 'care as usual' on reducing falls in community-dwelling older fallers. Design: randomised multicentre trial.
Beeck, E.F. (Ed) van, Boyé, N.D.A., Boyé, N.D.A. (Nicole), Cammen, T.J.M. (Tischa) van der, De Vries, O.J. (Oscar J.), Hartholt, K.A. (Klaas A.), Hartholt, K.A. (Klaas), Kerver, A.J.H. (Albert J.H.), Lieshout, E.M.M. (Esther) van, Lieshout, E.M.M. (Esther) van, Lips, P., Lips, P. (Paul), Looman, C.W.N. (Caspar), Mattace Raso, F.U.S. (Francesco), Mattace-Raso, F.U.S. (Francesco U.S.), Patka, P., Patka, P. (Peter), Polinder, S. (Suzanne), Van Beeck, E.F. (Ed F.), van der Cammen, T.J.M., van der Velde, N., Velde, N. (Nathalie) van der, Vries, O.J. (Oscar) de   +22 more
core   +5 more sources

Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID‐19

International Journal of Biomaterials, Volume 2022, Issue 1, 2022., 2022
The COVID‐19 pandemic has once again prompted people to resort to the remedies of folk and alternative medicine. Medicinal plants, because of their chemical composition, pharmacological properties, and the action of biologically active substances, can stop and relieve the symptoms of the disease.
Viktor Kamkin, Aidana Kamarova, Baurzhan Shalabayev, Assyltas Kussainov, Marat Anuarbekov, Serik Abeuov, Sameh Ali   +6 more
wiley   +1 more source

Trends in Prevalence of Gout Among US Asian Adults, 2011-2018

JAMA Network Open, 2023
Key Points Question Does the prevalence of gout differ between Asian and White adults in the US, and are social and clinical factors associated with the variation?
C. Yokose, N. McCormick, N. Lu, S. Tanikella, K. Lin, A. Joshi, L. Raffield, Erica T. Warner, T. Merriman, John Hsu, K. Saag, Yuqing Zhang, Hyon K. Choi   +12 more
semanticscholar   +1 more source

Self‐reported medication intake vs information from other data sources such as pharmacy records or medical records: Identification and description of existing publications, and comparison of agreement results for publications focusing on patients with cancer ‐ a systematic review

Pharmacoepidemiology and Drug Safety, Volume 30, Issue 5, Page 531-560, May 2021., 2021
Abstract Purpose To identify and describe publications addressing the agreement between self‐reported medication and other data sources among adults and, in a subgroup of studies dealing with cancer patients, seek to identify parameters which are associated with agreement. Methods A systematic review including a systematic search within five biomedical
Manuela Brüne, Carina Emmel, Gisela Meilands, Silke Andrich, Sigrid Droste, Heiner Claessen, Fabian Jülich, Andrea Icks   +7 more
wiley   +1 more source

Global, Regional, and National Prevalence of Gout From 1990 to 2019: Age-Period-Cohort Analysis With Future Burden Prediction

JMIR Public Health and Surveillance, 2023
Background Gout is a common and debilitating condition that is associated with significant morbidity and mortality. Despite advances in medical treatment, the global burden of gout continues to increase, particularly in high–sociodemographic index (SDI ...
Qiyu He, T. Mok, Tat-Hang Sin, Jiaying Yin, Sicun Li, Yiyue Yin, Waikit Ming, B. Feng   +7 more
semanticscholar   +1 more source

Direct healthcare professional communications: A quantitative assessment study

Pharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Abstract A retrospective observational study evaluated the direct healthcare professional communication (DHPC) letters disseminated by the Saudi Food and Drug Authority (SFDA) and their compliance with the pharmacovigilance guidelines. The study was utilized all DHPC letters available on the SFDA website, which is intended to communicate drug safety ...
Hajar Alsaleh, Thamir M. Alshammari
wiley   +1 more source

Combinatory Effects of Bone Marrow‐Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant‐Induced Arthritis in Wistar Rats: Roles of IL‐1β, IL‐4, Nrf‐2, and Oxidative Stress

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Rheumatoid arthritis (RA) is a disorder triggered by autoimmune reactions and related with chronic inflammation and severe disability. Bone Marrow‐derived Mesenchymal Stem Cells (BM‐MSCs) have shown a hopeful immunomodulatory effect towards repairing cartilage and restoring joint function.
Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Emad A. Mahdi, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour, Arham Shabbir   +7 more
wiley   +1 more source