Results 31 to 40 of about 929 (110)

Additional file 3 of Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

, 2022
Additional file 3. Supplementary methods.
Guma, Monica, Dadpey, Benyamin, Coras, Roxana, Mikuls, Ted R., Hamilton, Bartlett, Quehenberger, Oswald, Thorisdottir, Hilda, Bittleman, David, Lauro, Kimberly, Reilly, Shannon M., Liu-Bryan, Ru, Terkeltaub, Robert   +11 more
openaire   +1 more source

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Advanced Science, Volume 11, Issue 1, January 5, 2024.
Deregulated Inflammation is one of the most common diseases in human health, and its management remains a significant challenge. Notably, stimulus‐responsive hydrogels have great potential to break through the predicament faced by severe inflammations treatment.
Haoyu Yu, Rongyao Gao, Yuxin Liu, Limin Fu, Jing Zhou, Luoyuan Li   +5 more
wiley   +1 more source

Pentagalloyl glucose Suppresses MSU Crystal–Induced Gout Inflammation and Arachidonic Acid Production In Vitro and In Vivo

Frontiers in Pharmacology
Abstract Background Gout is an acute inflammatory arthritis triggered by monosodium urate (MSU) crystal deposition and activation of innate immune responses. In addition to inflammasome signaling, emerging evidence suggests that metabolic reprogramming of arachidonic acid (AA) pathways amplifies ...
Sadiq Umar, Yu Lu, Sugasini Dhavamani, Poorna CR Yalagala, Matez S Wietecha, Sriram Ravindran   +5 more
openaire   +2 more sources

Chinese classical decoction Wuwei Xiaodu Drink alleviates gout arthritis by suppressing NLRP3-Mediated inflammation

Frontiers in Pharmacology
Background: Wuwei Xiaodu Drink (WWXDD), a classical decoction of traditional Chinese medicine, has been clinically used for the treatment of gout in China for many years. This study aimed to demonstrate the efficacy of WWXDD in treating gout flares and elucidate its underlying therapeutic mechanism.Methods: A randomized control trial was conducted to ...
Na Lin, Qiaoding Dai, Yan Zhang, Liping Xu   +3 more
openaire   +3 more sources

How common are side effects of treatment to prevent gout flares when starting allopurinol?

The studyRoddy E, Bajpai R, Forrester H, et al. Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.
Roddy, Edward, Deeney, Brendan, Swaithes, Laura, Saul, Helen   +3 more
core   +1 more source

Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation

Acta Pharmacologica Sinica
Abnormal activation of NLRP3 inflammasome causes the progression of gout, and no small-molecule inhibitor of NLRP3 has been approved yet for clinical use. In this study we established a nigericin-induced inflammasome activation cell model for screening of a natural product library by measuring IL-1β secretion in cell supernatants.
Yan, Le-jin, Qi, Shuang, Wu, Chao, Jin, Rui, Hu, Chen, Wang, Ao-li, Wang, Bei-lei, Yu, Hong-wei, Wang, Li, Liu, Jing, Qi, Zi-ping, Wang, Wen-chao, Liu, Qing-song   +12 more
openaire   +3 more sources

UEG Week 2020 Oral Presentations

, 2020
United European Gastroenterology Journal, Volume 8, Issue S8, Page 8-142, October 2020.
wiley   +1 more source

Foreign Competition and the UK [PDF]

This paper, which seeks to identify factors contributing to the rate and character of technical transfer and to assess host-country research and development effort in response to foreign competition, is one of three examining the impact of technically ...
Arthur W. Lake
core  

Additional file 1: Figure S1. of Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression

, 2017
The Raw 264.7 cells were treated with or without LPS (1 μg/ml) for 6 h and then stimulated with MSU crystals for another 6 h. Figure S2. The levels of ROS were assessed by calculating the ratio of positive-staining cells among 10,000 cells using flow cytometry. Raw 264.7 cells were treated with procyanidins (10 μM) for 20 min and then stimulated by MSU
Liu, Hai-Jiao, Pan, Xiu-Xiu, Liu, Bing-Qian, Gui, Xuan, Hu, Liang, Jiang, Chun-Yi, Han, Yuan, Fan, Yi-Xin, Tang, Yu-Lin, Liu, Wen-Tao   +9 more
openaire   +1 more source

UEG Week 2024 Oral Presentations

United European Gastroenterology Journal, Volume 12, Issue S8, Page 9-200, October 2024.
wiley   +1 more source