Results 21 to 30 of about 937 (121)

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis

ChemistryOpen, Volume 14, Issue 12, December 2025.
A regioselective synthesis of fused thiazoles was achieved via aza‐Michael cyclization of thiazolidinone derivatives with hydrazines or heteroaryl amines. Density functional theory, local reactivity indices, and molecular electrostatic potential mapping are used to explain selectivity.
Ghaferah H. Al‐Hazmi, Jehan Y. Al‐Humaidi, Sayed M. Riyadh, Mohamed S. M. Ahmed, Magdi E. A. Zaki, Awatif H. Alruwaili, Khaled A. Alanazi, Rajeh H. Almutairi, Sobhi M. Gomha   +8 more
wiley   +1 more source

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma

The Journal of Physiology, Volume 603, Issue 15, Page 4409-4432, 1 August 2025.
Abstract figure legend PANX1 and PANX3 show opposite expression patterns in patient‐derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. Within the tumour PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour ...
Brooke L. O'Donnell, Danielle Johnston, Ayushi Bhatt, Zahra Kardan, Dan Stefan, Andrew Bysice, Samar Sayedyahossein, Lina Dagnino, Matthew Cecchini, Sampath Kumar Loganathan, Kathryn Roth, Silvia Penuela   +11 more
wiley   +1 more source

Maternal Nutritional Environment and the Development of the Melanocortin System

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Maternal metabolic impairments are related to an increased risk of obesity in the offspring throughout life, and changes in the development of the melanocortin system may be one of the mechanisms that promote increased food intake in the long term, leading to a positive energy balance and increased fat deposition.
Marina Galleazzo Martins, Alfonso Abizaid   +1 more
wiley   +1 more source

Correlation of Serum Growth Differentiation Factor 15 With Metabolic Syndrome and Its Components in Patients With Type 2 Diabetes Mellitus

Journal of Diabetes Research, Volume 2025, Issue 1, 2025.
Purpose The purpose of this study is to explore the association between serum growth differentiation factor 15 (GDF15) and metabolic syndrome (MS), as well as its components in patients with Type 2 diabetes mellitus (T2DM). Patients and Methods Data on 125 patients with T2DM admitted to the Department of Endocrinology of the Second People′s Hospital of
Yiran Zhao, Yonghong Cao, Yue Li, Xinxiu Zhang, Wu Dai, Jiajia Song, Dechao Yin, Xiaofang Han, Ricardo Cobucci   +8 more
wiley   +1 more source

Exploring the ancient roots and modern global brews of tea and herbal beverages: A comprehensive review of origins, types, health benefits, market dynamics, and future trends

Food Science &Nutrition, Volume 12, Issue 10, Page 6938-6955, October 2024.
Explores herbal teas and herbal beverages for their origins, types and trade history. Valuable insights into the market dynamic and future prospects of herbal beverage. Herbal beverages' bioactive components and their health‐promoting applications Abstract Tea, a culturally significant beverage, originated around 2700 B.C.
Hisham‐Sultan‐Alkatib Huda, Nazia Binti Abdul Majid, Yeng Chen, Mohd Adnan, Syed Amir Ashraf, Marek Roszko, Marcin Bryła, Marek Kieliszek, Sreenivasan Sasidharan   +8 more
wiley   +1 more source

Efficacy and safety of intragastric expandable oral capsules in adults with overweight or obesity: A randomized, double‐blind, placebo‐controlled trial

Diabetes, Obesity and Metabolism, Volume 26, Issue 4, Page 1224-1233, April 2024.
Abstract Aim This trial assessed the efficacy and safety of 2.24 g intragastric expandable capsules twice per day versus placebo for weight management in adults with overweight or obesity. Methods This double‐blind, placebo‐controlled study included adults with a body mass index of at least 24 kg/m2 and no more than 40 kg/m2. In total, 280 participants
Difei Lu, Zhenfang Yuan, Xiaohui Guo, Liyong Zhu, Fan Zhang, Xuejun Li, Wenbo Wang, Huandong Lin, Jingnan Luo   +8 more
wiley   +1 more source

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Advanced Science, Volume 11, Issue 1, January 5, 2024.
Deregulated Inflammation is one of the most common diseases in human health, and its management remains a significant challenge. Notably, stimulus‐responsive hydrogels have great potential to break through the predicament faced by severe inflammations treatment.
Haoyu Yu, Rongyao Gao, Yuxin Liu, Limin Fu, Jing Zhou, Luoyuan Li   +5 more
wiley   +1 more source

Chinese classical decoction Wuwei Xiaodu Drink alleviates gout arthritis by suppressing NLRP3-Mediated inflammation

Frontiers in Pharmacology
Background: Wuwei Xiaodu Drink (WWXDD), a classical decoction of traditional Chinese medicine, has been clinically used for the treatment of gout in China for many years. This study aimed to demonstrate the efficacy of WWXDD in treating gout flares and elucidate its underlying therapeutic mechanism.Methods: A randomized control trial was conducted to ...
Na Lin, Qiaoding Dai, Yan Zhang, Liping Xu   +3 more
openaire   +3 more sources

Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation

Acta Pharmacologica Sinica
Abnormal activation of NLRP3 inflammasome causes the progression of gout, and no small-molecule inhibitor of NLRP3 has been approved yet for clinical use. In this study we established a nigericin-induced inflammasome activation cell model for screening of a natural product library by measuring IL-1β secretion in cell supernatants.
Yan, Le-jin, Qi, Shuang, Wu, Chao, Jin, Rui, Hu, Chen, Wang, Ao-li, Wang, Bei-lei, Yu, Hong-wei, Wang, Li, Liu, Jing, Qi, Zi-ping, Wang, Wen-chao, Liu, Qing-song   +12 more
openaire   +3 more sources

Pentagalloyl glucose Suppresses MSU Crystal–Induced Gout Inflammation and Arachidonic Acid Production In Vitro and In Vivo

Frontiers in Pharmacology
Abstract Background Gout is an acute inflammatory arthritis triggered by monosodium urate (MSU) crystal deposition and activation of innate immune responses. In addition to inflammasome signaling, emerging evidence suggests that metabolic reprogramming of arachidonic acid (AA) pathways amplifies ...
Sadiq Umar, Yu Lu, Sugasini Dhavamani, Poorna CR Yalagala, Matez S Wietecha, Sriram Ravindran   +5 more
openaire   +2 more sources