Results 21 to 30 of about 929 (110)

AB0074 Daily exercise suppresses acute pro-inflammatory cytokine expression systemically and il-1Β locally in a murine model of gout [PDF]

Annals of the Rheumatic Diseases, 2018
Background Recent gout clinical practice recommendations/guidelines released by the ACR (2012) and the ACP (2017) do not address exercise as an interventional strategy; in contrast, the 2016 EULAR gout recommendations suggest that regular physical activity might decrease the excess mortality associated with chronic hyperuricemia.
N.A. Young, K. Jablonski, B. Sandoval, A. Kalyanasundaram, P. Harb, J. Hampton, W. Jarjour, N. Schlesinger   +7 more
openaire   +1 more source

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis

ChemistryOpen, Volume 14, Issue 12, December 2025.
A regioselective synthesis of fused thiazoles was achieved via aza‐Michael cyclization of thiazolidinone derivatives with hydrazines or heteroaryl amines. Density functional theory, local reactivity indices, and molecular electrostatic potential mapping are used to explain selectivity.
Ghaferah H. Al‐Hazmi, Jehan Y. Al‐Humaidi, Sayed M. Riyadh, Mohamed S. M. Ahmed, Magdi E. A. Zaki, Awatif H. Alruwaili, Khaled A. Alanazi, Rajeh H. Almutairi, Sobhi M. Gomha   +8 more
wiley   +1 more source

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma

The Journal of Physiology, Volume 603, Issue 15, Page 4409-4432, 1 August 2025.
Abstract figure legend PANX1 and PANX3 show opposite expression patterns in patient‐derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. Within the tumour PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour ...
Brooke L. O'Donnell, Danielle Johnston, Ayushi Bhatt, Zahra Kardan, Dan Stefan, Andrew Bysice, Samar Sayedyahossein, Lina Dagnino, Matthew Cecchini, Sampath Kumar Loganathan, Kathryn Roth, Silvia Penuela   +11 more
wiley   +1 more source

Maternal Nutritional Environment and the Development of the Melanocortin System

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Maternal metabolic impairments are related to an increased risk of obesity in the offspring throughout life, and changes in the development of the melanocortin system may be one of the mechanisms that promote increased food intake in the long term, leading to a positive energy balance and increased fat deposition.
Marina Galleazzo Martins, Alfonso Abizaid   +1 more
wiley   +1 more source

Additional file 1 of Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

, 2022
Additional file 1: Supplementary Figure 1. PLS-DA and RF analysis of serum metabolomic profiling at time zero. PLS-DA and RF analysis at time zero resulted in a good discrimination and prediction of the samples per BMI (A), but not per number of flares (B), or hyperuricemia (HU) > 8 mg/dL (C), or presence of tophi (D). Supplementary Figure 2.
Guma, Monica, Dadpey, Benyamin, Coras, Roxana, Mikuls, Ted R., Hamilton, Bartlett, Quehenberger, Oswald, Thorisdottir, Hilda, Bittleman, David, Lauro, Kimberly, Reilly, Shannon M., Liu-Bryan, Ru, Terkeltaub, Robert   +11 more
openaire   +1 more source

Correlation of Serum Growth Differentiation Factor 15 With Metabolic Syndrome and Its Components in Patients With Type 2 Diabetes Mellitus

Journal of Diabetes Research, Volume 2025, Issue 1, 2025.
Purpose The purpose of this study is to explore the association between serum growth differentiation factor 15 (GDF15) and metabolic syndrome (MS), as well as its components in patients with Type 2 diabetes mellitus (T2DM). Patients and Methods Data on 125 patients with T2DM admitted to the Department of Endocrinology of the Second People′s Hospital of
Yiran Zhao, Yonghong Cao, Yue Li, Xinxiu Zhang, Wu Dai, Jiajia Song, Dechao Yin, Xiaofang Han, Ricardo Cobucci   +8 more
wiley   +1 more source

Conveying meaning through design in a safety critical medical system [PDF]

, 2006
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityMedication errors account for a significant number of medical errors. Giving medications to patients is an activity that carries a high risk of error.
Lane, Rhonda Maria
core  

Exploring the ancient roots and modern global brews of tea and herbal beverages: A comprehensive review of origins, types, health benefits, market dynamics, and future trends

Food Science &Nutrition, Volume 12, Issue 10, Page 6938-6955, October 2024.
Explores herbal teas and herbal beverages for their origins, types and trade history. Valuable insights into the market dynamic and future prospects of herbal beverage. Herbal beverages' bioactive components and their health‐promoting applications Abstract Tea, a culturally significant beverage, originated around 2700 B.C.
Hisham‐Sultan‐Alkatib Huda, Nazia Binti Abdul Majid, Yeng Chen, Mohd Adnan, Syed Amir Ashraf, Marek Roszko, Marcin Bryła, Marek Kieliszek, Sreenivasan Sasidharan   +8 more
wiley   +1 more source

Efficacy and safety of intragastric expandable oral capsules in adults with overweight or obesity: A randomized, double‐blind, placebo‐controlled trial

Diabetes, Obesity and Metabolism, Volume 26, Issue 4, Page 1224-1233, April 2024.
Abstract Aim This trial assessed the efficacy and safety of 2.24 g intragastric expandable capsules twice per day versus placebo for weight management in adults with overweight or obesity. Methods This double‐blind, placebo‐controlled study included adults with a body mass index of at least 24 kg/m2 and no more than 40 kg/m2. In total, 280 participants
Difei Lu, Zhenfang Yuan, Xiaohui Guo, Liyong Zhu, Fan Zhang, Xuejun Li, Wenbo Wang, Huandong Lin, Jingnan Luo   +8 more
wiley   +1 more source

Montelukast suppresses NLRP3 inflammasome activation as a potential prophylactic agent against gout arthritis flares

Journal of Inflammation
Gout arthritis (GA) flares are unexpected bouts of heat, swelling, and redness resulting in excruciating pain caused by monosodium urate (MSU) crystal deposition in the synovial joints. GA flare symptoms occur as a by-product of the inflammatory response as immune cells engulf MSU crystals in the joint. The NLRP3 inflammasome is the major source of the
Shippy, Daniel C., Evered, Abigail H., Ulland, Tyler K.   +2 more
openaire   +3 more sources