Results 91 to 100 of about 9,244 (205)

Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.

PLoS ONE
ObjectiveThe Toll-like receptor (TLR) 4-mediated nuclear factor kappa B (NF-κB) signaling pathway regulates the production of inflammatory factors and plays a key role in the pathogenesis of gouty arthritis.
Lu Liu, Shuang He, Lin Jia, Hua Yao, Dan Zhou, Xiaobin Guo, Lei Miao   +6 more
doaj   +1 more source

A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain, Sukyung Kim, Md Tareque Aziz, Izaz Ahmed, Md Sarower Hossen Shuvo, Hyewon Yang, Yunjeong Jang, Minseo Kim, Seohyeon Jang, Yusol Kim, Soeun Oh, Yunseo Nam, Hoonhee Seo, Ho‐Yeon Song   +13 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

CodeMergeR: A Shiny‐Based Application for Codelist Integration

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 10, October 2026.
ABSTRACT Objective To describe CodeMergeR, an open‐source R shiny application developed within the VAC4EU network for the standardization, cleaning, and integration of individual concept codelists into a master file for real‐world evidence (RWE) studies. Materials and Methods CodeMergeR was designed to process codelists exported by CodeMapper v1.0. The
Vjola Hoxhaj, Judit Riera‐Arnau, Sima Mohammadi, Miriam C. J. M. Sturkenboom, Constanza L. Andaur Navarro   +4 more
wiley   +1 more source

Clinical Application of Acupuncture and Moxibustion to the Treatment of Gouty Arthritis and Analysis on Their Therapeutic Effects

针刺研究, 2009
In the present paper,the authors make a summary on the clinical application of acu-moxibustion therapy in the treatment of gouty arthritis in recent 10 years.Acupuncture needles often used are filiform needle,red-hot needle,moxibustion-warmed needle and ...
LIN Cai-xia, MA Hui-fang, MA Wen-zhu, ZHOU Pei-juan1   +3 more
doaj   +2 more sources

Obesity, Echocardiographic Changes and Framingham Risk Score in the Spectrum of Gout: A Cross-Sectional Study

The Turkish Journal of Gastroenterology, 2019
Objectives: This study aims to establish cardiovascular risk in obese and non-obese patients in stages of gout by using Framingham risk score (FRS) and transthoracic echocardiography.
Rada GANCHEVA, Atanas KOUNDURDJIEV, Mariana IVANOVA, Todor KUNDURZHIEV, Zlatimir KOLAROV   +4 more
doaj  

Photoinitiator-free gelatin hydrogel microneedles for acute gouty arthritis treatment. [PDF]

Sci Adv
Zhang J, Zhang H, Wang T, Liu W, Xia B, Huang L, Wu H, Li Y, Gu Z.   +8 more
europepmc   +1 more source

Multimetal-Doped Nanoenzymes Reprogram Macrophages for Immunotherapy of Gouty Arthritis. [PDF]

Adv Healthc Mater
Zhou S, Zhang WQ, Li Y, Gao RF, Ma JY, Cheng K, Fan JX, Yang J, Dong LL, Liu B.   +9 more
europepmc   +1 more source

Yinlian Tongfeng Granules: A Promising Clinical Treatment Option for Gouty Arthritis. [PDF]

Int J Rheum Dis
Xie M, Ding X, Zhai X, Li M, Zhou M.
europepmc   +1 more source