Results 71 to 80 of about 9,319 (197)

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

A rare and asymptomatic case of mitral valve tophus associated with severe gouty tophaceous arthritis

, 2004
Gouty arthritis is characterized by the deposition of monosodium urate crystals in the joints and soft tissues. Clinical manifestations include acute and chronic arthritis and tophaceous deposits.
Iacobellis, G
core   +1 more source

Effect of Long‐Term Non‐Weight Bearing on the Morphology and Function of the Heel Fat Pad

Journal of Foot and Ankle Research, Volume 19, Issue 2, June 2026.
ABSTRACT Background We aimed to investigate the effects of long‐term non‐weight‐bearing conditions, including prolonged bedridden states, on the morphology and function of the heel fat pad. Methods We recruited 13 elderly individuals bedridden for over 1 year (BR group) and 89 age‐matched healthy controls (CON group) living independently.
Toshihiro Maemichi, Masatomo Matsumoto, Toshiharu Tsutsui, Tsukasa Kumai   +3 more
wiley   +1 more source

Gouty arthritis in the human aging process

, 2012
The aging process has gained universal recognition and is occurring at an accelerated pace. Gout is a metabolic disorder in which an overproduction and / or decreased excretion of uric acid, leading to the deposition of crystals of sodium monourato ...
Lia Mara Wibelinger, Juliana Secchi Batista   +1 more
core  

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

TREM‐1 Blockade Inhibits Inflammasome Activation and Pyroptosis: Novel Insights on the Role of TREM‐1 and Syk in Monosodium Urate Crystal‐Induced Inflammation

Immunology, Volume 178, Issue 2, Page 249-260, June 2026.
Schematic overview of the roles triggering receptor expressed on myeloid cells‐1 (TREM‐1) plays in monosodium urate (MSU) crystal‐induced inflammasome activation and IL‐1β secretion in gout arthritis. The present study provides novel data suggesting that blockade of TREM‐1 by LP17 attenuates MSU‐crystal‐induced inflammation through inhibition of ...
Yair Molad, Irina Lagovsky, Vitaly Kliminski   +2 more
wiley   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Co-regulated ceRNA network mediated by circRNA and lncRNA in patients with gouty arthritis

Numerous studies have demonstrated the involvement of messenger RNAs (mRNAs) and non-coding RNAs, including long non-coding RNAs (lncRNA), circular RNAs (circRNAs) and microRNA (miRNAs), in gouty arthritis onset; however, the regulatory mechanism has not
Jinkun Liu, Wenfu Cao, Jiayu Tian, Miao Wang, Yanqiu Xu, Bin wu   +5 more
core   +1 more source

From Harvest to Health: A Systems‐Based Evaluation of FarmsSHARE's Impact on Nutrition in North Carolina

Journal of Human Nutrition and Dietetics, Volume 39, Issue 3, June 2026.
ABSTRACT Background Persistent food insecurity and diet‐related chronic disease in North Carolina underscore the need for systems‐based approaches in nutrition and dietetics. Small‐ and medium‐scale farms face barriers to consistent markets, while food‐insecure households encounter limited access to fresh, culturally relevant foods.
Amanda Hege, Heather Schier, Juliana Grant, Dave Walker, Monica McCann   +4 more
wiley   +1 more source