Results 101 to 110 of about 14,154 (239)

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

In vitro cell-based Hyperuricemia-hemotest bioassay for cytokine status evaluation in patients with gouty arthritis [PDF]

Наука и инновации в медицине
Aim– to develop anin vitromethod for assessing the activity of the inflammasome under conditions of hyperuricemic stimulation of inflammatory interleukins.
Larisa Т. Volova, Evgenii I. Pugachev, Tatyana V. Starikova, Petr А. Lebedev, Irina А. Shafieva, Sergei I. Kuznetsov, Oksana А. Gusyakova, Galina N. Svetlova, Natalya K. Osina   +8 more
doaj   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Cell-based in vitro hemoassay for evaluation of NLRP3-inflammasome activity

Медицинская иммунология
Currently, gouty arthritis is considered as a polygenic multifactorial autoinflammatory disease caused by activation of the NOD (nucleotide-binding domain) -like protein receptor 3 inflammasome NLRP3.
N. K. Ossina, L. T. Volova, P. A. Lebedev, I. A. Shafieva, E. I. Pugachev, S. A. Goncharenko, S. I. Kuznetsov, O. A. Gusyakova, G. N. Svetlova   +8 more
doaj   +1 more source

Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis.

PLoS ONE, 2017
BackgroundGout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals.
Jin-Hui Tao, Miao Cheng, Jiang-Ping Tang, Xiao-Juan Dai, Yong Zhang, Xiang-Pei Li, Qin Liu, Ya-Ling Wang   +7 more
doaj   +1 more source

Inflammatory Bowel Disease in Patients With Atopic Dermatitis and Allergic Rhinitis: A Nationwide Case–Control Study

International Journal of Rheumatic Diseases, Volume 29, Issue 3, March 2026.
ABSTRACT Introduction Inflammatory bowel disease (IBD) has been associated with several allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma. However, the correlations between these conditions vary—some are positively correlated, and some are negatively correlated. To address these discrepancies, this study explored the risk of
Chung‐Fang Tseng, Meng‐Che Wu, Yu‐Hsun Wang, Jing‐Yang Huang, Hsiao‐Chen Lin, Te‐Chia Tseng, Chih‐Jung Yeh, Jame Cheng‐Chung Wei   +7 more
wiley   +1 more source

Determination of gouty arthritis' biomarkers in human urine using reversed-phase high-performance liquid chromatography

Journal of Pharmaceutical Analysis, 2014
Creatinine, uric acid, hypoxanthine and xanthine are important diagnostic biomarkers in human urine for gouty arthritis or renal disease diacrisis. A simple method for simultaneous determination of these biomarkers in urine based on reversed-phase high ...
Lei-Wen Xiang, Jing Li, Jin-Ming Lin, Hai-Fang Li   +3 more
doaj   +1 more source

Primary and Secondary Grzybowski’s Generalized Eruptive Keratoacanthoma: A New Perspective on Management, Clinical Features, and Prognosis

International Journal of Dermatology, Volume 65, Issue 3, Page 456-463, March 2026.
ABSTRACT Grzybowski's generalized eruptive keratoacanthoma (GEKA) is a rare variant of keratoacanthomas, characterized by hundreds to thousands of lesions, accompanied by pruritus, mucosal involvement, and comorbidities. Our aim was to analyze the clinical presentation, associated comorbidities, treatment strategies, and outcomes of GEKA.
Nicholas Florin Kormos, Carina Maria Petrenciu, Alin Stefan Vizitiu, Raluca Ghețe, Umer Nadir, Adrian Lucian Baican, Stanislav N. Tolkachjov   +6 more
wiley   +1 more source

Preparative separation of profen enantiomers by liquid chromatography [PDF]

, 2007
Profens. or 2-aryfpropionic acids. are an important sub-class of the frequently prescribed non-steraidal anti-inflammatory drugs (NSAIDs). Some of the main primary indications for NSAIDs therapy include rheumatoid arthritis, osteoarthritis, acute gouty ...
Graça, Nuno S., Pais, Luís S., Ribeiro, António E., Rodrigues, Alírio   +3 more
core   +3 more sources

CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

Nature Communications
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation.
Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu   +16 more
doaj   +1 more source