Results 41 to 50 of about 1,634,233 (302)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Misogyny in Brazilian Federal Government Agencies for Science and High-Education
Anais da Academia Brasileira de Ciências, 2021 The transformation of women’s role in society has been systematically studied. Numerous authors point out that among the factors of extreme relevance to this fact, the main is the increased presence of women in the formal job market.
ROBERTA PEIXOTO ARÊAS DA SILVA +4 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Critique [of Racism and the Canadian State by Daiva K. Stasiulis] [PDF]
, 1985 Stasiulis\u27s two-part essay offers a critique of the policies on immigration and racism pursued by the Canadian government during the past decade or so.
Hoglund, A. William
core +1 more source
Modernisation, managerialism and the culture wars: the reshaping of the local welfare state in England [PDF]
, 2004 The story of local government over the last few decades is often summarised in the assertion that there has been a move away from institutional authority embodied in the structures of councils towards more complex networks of local governance ...
Cochrane, Allan
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
40 Years of FOIA, 20 Years of Delay: Oldest Pending Freedom of Information Requests Date Back to the 1980s [PDF]
, 2007 Presents findings from the Knight Open Government Survey, which surveys government offices and agencies on the status of their public information requests, and finds that extensive backlogs ...
Catherine Nielsen
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Design and development of wisdom-based organization model in government agencies [PDF]
مدیریت دولتی, 2015 The importance of wisdom in managerial and organizational issues is growing. Wisdom, in addition to being the rational and moral judgment, is the most important success factor for organization.
Morteza Moradi
doaj +1 more source