Results 61 to 70 of about 1,634,233 (302)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Disability Employment Policies and Practices in U.S. Federal Government Agencies [PDF]
, 1999 A survey of U.S. Federal agencies was initiated by the Presidential Task Force on Employment of Adults with Disabilities, and 403 representatives of U.S.
Bruyere, Susanne M, Horne, Richard L
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Flat conductor cable survey [PDF]
, 1973 Design handbook contains data and illustrations concerned with commercial and Government flat-conductor-cable connecting and terminating hardware.
Swanson, C. R., Walker, G. L.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Environmental scanning and analysis in Swedish central government agencies
Offentlig Förvaltning: Scandinavian Journal of Public Administration, 2012 <p>Most government agencies have some form of environmental scanning, but few have dedicated departments or full-time staff responsible for analysis.
Torbjörn Lundqvist
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Digital Government and Public Health
Preventing Chronic Disease, 2004 Digital government is typically defined as the production and delivery of information and services inside government and between government and the public using a range of information and communication technologies.
Jane E. Fountain
doaj
How do government agencies use evidence? [PDF]
Executive summary: Significant research gaps remain in our understanding about what happens in side government agencies in relation to the production, commissioning, assessment and incorporation of research-based evidence into their policy advice and ...
Brian Head
core