Results 71 to 80 of about 4,999,446 (322)

The Argument Against a Government Resolution Authority [PDF]

open access: yes, 2009
Argues against the proposal to authorize government agencies to resolve failed or failing "systemically important" nonbank financial institutions as a way to avoid systemic breakdowns.
Peter J. Wallison
core  

Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment [PDF]

open access: yes, 2015
Acknowledgements This study was possible by partial financial support from the following Brazilian government agencies: Fundação Araucária, EPSRC-EP/I032606/1 and CNPq, CAPES and Science Without Borders Program Process nos. 17656125, 99999.010583/2013-00
Baptista, Murilo Da Silva   +7 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Flat conductor cable survey [PDF]

open access: yes, 1973
Design handbook contains data and illustrations concerned with commercial and Government flat-conductor-cable connecting and terminating hardware.
Swanson, C. R., Walker, G. L.
core   +1 more source

E-government 4.0 in Thailand: The role of central agencies

open access: yesInf. Polity, 2018
This study discusses Thailand’s digital transformation efforts with a focus on the leadership roles of its central government agencies. Thailand has progressed through various e-government policy frameworks since the 1990s, and the current military ...
Danuvas Sagarik   +3 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

TQM-ing OMB: Or Why Regulatory Review Under Executive Order 12,291 Works Poorly and What President Clinton Should Do About It [PDF]

open access: yes, 1994
Reflections are presented on how Pres Clinton should improve the deeply troubled relationship between the OMB and other government agencies.
Eklund, Britta   +2 more
core   +3 more sources

FAKTOR-FAKTOR YANG MEMPENGARUHI KESIAPAN PENERAPAN SAP BERBASIS AKRUAL DAN AKUNTABILITAS KINERJA INSTANSI PEMERINTAH (STUDI EMPIRIS PADA PEMERINTAH DAERAH KABUPATEN DOMPU)

open access: yesJurnal Akuntansi Aktual, 2019
The successful implementation of accrual-based GovernmentAccounting Standard is a very important thing that will have an impact on performance accountability of government agencies, then it is necessary for the identification of the factors that can ...
Ajhar ., Akram ., Endar Pituringsih
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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