Results 71 to 80 of about 5,265,671 (332)

High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models

open access: yesNature Communications
Missense mutations in the 12th codon of KRAS are key drivers of lung cancer, with glycine-to-cysteine (G12C) and glycine-to-aspartic acid (G12D) substitutions being among the most prevalent.
Juan Carlos Álvarez-Pérez   +10 more
doaj   +1 more source

Modernization of the Mechanism of State Regulation of Regional Russian Agro-Industrial Complex Under New Social and Economic Constructs

open access: yesVestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 3, Èkonomika,Èkologiâ, 2014
The article highlights the obstacles in building the necessary amount of food and in ensuring the full import substitution based on the efficient use of the available resources: Russia’s lagging behind economically developed countries in the technical ...
Babich Tatyana Vladimirovna   +2 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Public Health and Bioethics, Reflections on Sars-Cov-2 (Covid-19) in Colombia

open access: yesRevista Cuidarte, 2020
La rápida propagación de la enfermedad COVID-19 ha generado el establecimiento de mecanismos de coordinación, control y acciones prolongadas por parte de los actores y/o agentes, lo que ha desencadenado barreras fronterizas entre las comunidades y las ...
Consuelo Vélez Álvarez   +2 more
doaj   +1 more source

An optimization model for investment in technology and government regulation

open access: yesWireless networks, 2019
Companies struggle every day to estimate the adequate level of investment in new technologies, and governments lack the tools to determine the impact of their regulations on industry including telecommunications networks. Despite these facts, few studies
Mario M. Monsreal-Barrera   +3 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Rechtsvacuum Phenomenon in Government Regulation of the Republic of Indonesia Number 51 of 2020 related to Passport Renewal Period to 10 Years

open access: yesJournal of Law and Border Protection, 2019
Legislation is one of the legal products issued by the state government component. In this case, the laws and regulations include the Constitution of the Republic of Indonesia year 1945, the Decree of the People's Consultative Assembly, The Law ...
Fachrizza Sidi Pratama
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

GOVERNMENT REGULATION OF HOUSING.

open access: yesХабаршысы. Экономика сериясы, 2015
В статье рассматривается современное состояние жилищного сектора и роль государственных программ в обеспечении жильем народа Республики Казахстан.
S. Orakbaeva
doaj  

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