Results 71 to 80 of about 1,632,372 (364)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
’Governance by Things’ as a challenge to regulation by law [PDF]
Internet Policy Review, 2016 In this paper the authors examine how the rise of the Internet of Things will challenge regulatory structures. Coming from the idea of “code as law” the shift from technology governing online spaces to physical spaces is described as a new phenomenon. They call it ‘Governance by Things’.
Dankert, Kevin, Schulz, Wolfgang
openaire +6 more sources
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Jurnal Borneo Administrator: Media Pengembangan Paradigma dan Gaya Baru Manajemen Pemerintahan Daerah, 2014 The important thing in the implementation of regional autonomy is there is freedom of local governments (discretionery power) to carry out self-government on the basis of initiative, creativity and role-and active community in order to develop and ...
Fani Heru Wismono
doaj +1 more source
The Size and Role of Government Economic Issues [PDF]
, 2008 [Excerpt] The size and role of the government is one of the most fundamental and enduring debates in American politics. Economics can be used to analyze the relative merits of government intervention in the economy in specific areas, but it cannot answer
Labonte, Marc
core +4 more sources
Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase
FEBS Letters, EarlyView.The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu +5 more
wiley +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Regulation with Budget Constraints Can Dominate Regulation by Price and by Quantity [PDF]
A government can use several mechanisms to induce firms to reduce pollution. Well studied are regulations by price and by quantity. We consider a third form of regulation -- government allocates a budget to an agency which subsidizes abatement.
Amihai Glazer, Linda Cohen
core
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source