Results 81 to 90 of about 2,763 (200)

Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection. [PDF]

PLoS Neglected Tropical Diseases, 2017
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes.
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero   +10 more
doaj   +1 more source

Genomes of marine cyanopodoviruses reveal multiple origins of diversity [PDF]

, 2012
The marine cyanobacteria Prochlorococcus and Synechococcus are highly abundant in the global oceans, as are the cyanophage with which they co-evolve. While genomic analyses have been relatively extensive for cyanomyoviruses, only three cyanopodoviruses ...
Angly, Avrani, Bergh, Bhaya, Botstein, Bragg, Breitbart, Brody, Béjà, Chen, Chen, Chenard, Cock, Coleman, Coleman, Comeau, Dongen, Doulatov, Dunn, Edgar, Edgar, Enav, Filée, Frias-Lopez, Fuhrman, Funk, Ghai, Guindon, Guy, He, Hendrix, Henn, Huang, Hunter, Ignacio-Espinoza, Jones, Kelly, Kettler, Krakauer, Labonté, Lavigne, Leiman, Leplae, Letunic, Letunic, Limor-Waisberg, Lindell, Lindell, Lindell, Liu, Liu, Liu, Liu, Liu, Liu, Malmstrom, Mann, Marchler-Bauer, McDaniel, Millard, Millard, Molineux, Ortmann, Partensky, Pavlova, Pope, Punta, Rocap, Rusch, Sabehi, Sabehi, Scanlan, Sharon, Shimodaira, Sonnhammer, Studier, Studier, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Summers, Suttle, Tettelin, Thingstad, Thompson, Uhl, Vogel, Waterbury, Waterbury, Weigele, Weinbauer, Wickham, Williamson, Wolfson, Wommack, Yerrapragada, Zdobnov, Zeidner, Zeng   +100 more
core   +1 more source

Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana. [PDF]

PLoS Neglected Tropical Diseases, 2019
INTRODUCTION:The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species.
Priscila Marques de Macedo, Marcus de Melo Teixeira, Bridget M Barker, Rosely Maria Zancopé-Oliveira, Rodrigo Almeida-Paes, Antonio Carlos Francesconi do Valle   +5 more
doaj   +1 more source

An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family [PDF]

, 2014
A mutant of the high fidelity family-B DNA polymerase from the archaeon Thermococcus gorgonarius (Tgo-Pol), able to replicate past DNA lesions, is described.
Aidan J. Doherty, Barry, Bebenek, Bernard A. Connolly, Biles, Boiteux, Braithwaite, Brautigam, Brian J. Keith, Burgers, Cadet, Cann, Cann, Cline, Cozens, Cubonová, Fenton, Firbank, Franklin, Gan, Goodman, Haracska, Haracska, Heller, Hogg, Ishino, Johnson, Johnson, Johnson, Joyce, Jozwiakowski, Jozwiakowski, Keith, Kelley, Kelman, Kim, Kunkel, Kunkel, Lawrence, Lawrence, Lawrence, Leadon, Leigh, Louise Gilroy, Lundberg, McCulloch, Nick McElhinny, Northam, Perera, Pettersen, Pfeifer, Prakash, Pursell, Rangarajan, Reha-Krantz, Sabouri, Sabouri, Sarmiento, Schneider, Shaw, Stanislaw K. Jozwiakowski, Stillman, Swan, Teoule, Terpe, Wang, Wang, Waters, Yang   +68 more
core   +1 more source

In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals

Molecular Medicine, 2003
One of the major drawbacks limiting the use of synthetic peptide vaccines in genetically distinct populations is the fact that different epitopes are recognized by T cells from individuals displaying distinct major histocompatibility complex molecules ...
L. Iwai, Márcia Yoshida, J. Sidney, M. Shikanai-Yasuda, A. Goldberg, M. Juliano, J. Hammer, L. Juliano, A. Sette, J. Kalil, L. Travassos, E. Cunha-Neto   +11 more
semanticscholar   +1 more source

Detection of antibodies to Paracoccidioides brasiliensis in horses from northern Region of Paraná State /
Detecção de anticorpos para Paracoccidioides brasiliensis em cavalos da região norte do Estado do Paraná

Semina: Ciências Agrárias, 2009
Paracoccidioidomycosis, caused by the dimorphic fungus Paracoccidioides brasiliensis, is the most prevalent human systemic mycosis in Latin America. Paracoccidioidomycosis affects mainly male rural workers, causing granulomatous lesions in organs such as
Mario Augusto Ono, Zoilo Pires de Camargo, Roberta Lemos Freire, Eiko Nakagawa Itano, Andréia Corrêa Corte   +4 more
doaj   +1 more source

T-Cell Recognition of Paracoccidioides brasiliensis gp43-Derived Peptides in Patients with Paracoccidioidomycosis and Healthy Individuals [PDF]

Clinical and Vaccine Immunology, 2007
ABSTRACT Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of
Leo Kei, Iwai, Márcia, Yoshida, Aya, Sadahiro, Washington Robert, da Silva, Maria Lucia, Marin, Anna Carla, Goldberg, Maria Aparecida, Juliano, Luiz, Juliano, Maria Aparecida, Shikanai-Yasuda, Jorge, Kalil, Edecio, Cunha-Neto, Luiz R, Travassos   +11 more
openaire   +2 more sources

Fidelity of DNA replication - a matter of proofreading [PDF]

, 2018
DNA that is transmitted to daughter cells must be accurately duplicated to maintain genetic integrity and to promote genetic continuity. A major function of replicative DNA polymerases is to replicate DNA with the very high accuracy. The fidelity of DNA
Bebenek, Anna, Ziuzia-Graczyk, Izabela
core   +1 more source

Acute juvenile Paracoccidioidomycosis: A 9-year cohort study in the endemic area of Rio de Janeiro, Brazil. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the genus Paracoccidioides. It is the most important systemic mycosis in Latin America and the leading cause of hospitalizations and death among them in
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Dayvison Francis Saraiva Freitas, Andréa Gina Varon, Ariane Gomes Paixão, Anselmo Rocha Romão, Ziadir Francisco Coutinho, Claudia Vera Pizzini, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle   +9 more
doaj   +1 more source

Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: Identification of putative homologues of Candida albicans virulence and pathogenicity genes [PDF]

, 2003
Paracoccidioides brasiliensis, a thermodimorphic fungus, is the causative agent of the prevalent systemic mycosis in Latin America, paracoccidioidomycosis. We present here a survey of expressed genes in the yeast pathogenic phase of P. brasiliensis.
Batista, Wagner L. [UNIFESP], Bernardes, Luciano Angelo de Souza, Bogossian, Ana Paula, Ferreira, Leslie Ecker., Goldman, Gustavo H., Goldman, Maria Helena S, Marques, Everaldo dos Reis, Moreira, Julio C., Nobrega, Francisco G., Nobrega, Marina Pasetto, Nunes, Luiz R., Oliveira, Regina C. de, Puccia, Rosana [UNIFESP], Quiapin, Andrea Carla, Ribeiro, Diogenes Custodio Duarte, Savoldi, Marcela, Semighini, Camile P., Tekaia, Fredj, Travassos, Luiz R. [UNIFESP], Vitorelli, Patricia Marostica   +19 more
core   +1 more source