Dendritic cells transfected with scFv from Mab 7.B12 mimicking original antigen gp43 induces protection against experimental Paracoccidioidomycosis. [PDF]
PLoS ONE, 2011 Paracoccidioidomycosis (PCM), endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis (P. brasiliensis), which primarily attacks lung tissue.
Karen S Ferreira +6 more
doaj +1 more source
Detection of Paracoccidioides brasiliensis gp43 Gene in Sputa by Loop‐Mediated Isothermal Amplification Method [PDF]
Journal of Clinical Laboratory Analysis, 2009 AbstractThe fungus Paracoccidioides brasiliensis is the pathogen of paracoccidioidomycosis (PCM), a systemic mycosis prevalent in Latin America. The loop‐mediated isothermal amplification method (LAMP) was used in this study to detect the presence of P. brasiliensis in sputa samples from patients with chronic PCM, suspected PCM, and a negative control.
B T, Tatibana +8 more
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Evidence for positive selection in putative virulence factors within the Paracoccidioides brasiliensis species complex. [PDF]
PLoS Neglected Tropical Diseases, 2008 Paracoccidioides brasiliensis is a dimorphic fungus that is the causative agent of paracoccidioidomycosis, the most important prevalent systemic mycosis in Latin America. Recently, the existence of three genetically isolated groups in P. brasiliensis was
Daniel R Matute +3 more
doaj +1 more source
PREVALENCE of PARACOCCIDIOIDOMYCOSIS INFECTION BY INTRADERMAL REACTION in RURAL AREAS in ALFENAS, MINAS GERAIS, BRAZIL [PDF]
, 2014 This study aimed to estimate the prevalence of paracoccidioidal infection by intradermal reaction (Delayed-Type Hypersensitivity, DTH) to Paracoccidioides brasiliensis in rural areas in Alfenas, Southern Minas Gerais (MG) State, Brazil, and to assess ...
Camargo, Zoilo Pires de +9 more
core +5 more sources
Paracoccidioides species complex : ecology, phylogeny, sexual reproduction, and virulence [PDF]
, 2014 Paracoccidioidomycosis (PCM) is a deep systemic mycosis caused by human fungal pathogens of the Paracoccidioides genus. The disease is geographically restricted to subtropical areas of Latin America (from south of Mexico to north of Argentina) with a ...
Bagagli, Eduardo +4 more
core +2 more sources
Polymorphism in the Gene Coding for the Immunodominant Antigen gp43 from the Pathogenic Fungus Paracoccidioides brasiliensis [PDF]
Journal of Clinical Microbiology, 2000 ABSTRACT The gp43 glycoprotein is an immune-dominant antigen in patients with paracoccidioidomycosis (PCM). It is protective against murine PCM and is a putative virulence factor. The gp43 gene of Paracoccidioides brasiliensis B-339 is located in a 1,329-bp DNA fragment that includes two exons, a 78-bp ...
F V, Morais +4 more
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Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats
Revista da Sociedade Brasileira de Medicina Tropical, 2019 INTRODUCTION: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats ...
Eduardo Alexandre Loth +5 more
doaj +1 more source
Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection. [PDF]
PLoS Neglected Tropical Diseases, 2017 Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes.
Rodrigo Assunção Holanda +10 more
doaj +1 more source
ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis [PDF]
, 2018 peer-reviewedCrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and representing up to 90% of human gut viromes, members of this
Draper, Lorraine A. +6 more
core +5 more sources
Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis [PDF]
Infection and Immunity, 1994 Extracellular matrix protein laminin binds specifically to yeast forms of Paracoccidioides brasiliensis and enhances adhesion of the fungus to the surface of epithelial Madin-Darby canine kidney cells in vitro. Immunoblotting of fungal extracts showed that the gp43 glycoprotein is responsible for adhesion.
Vicentini, A. P. +6 more
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