Atypical Serological Response Marked by a Lack of Detectable Anti-gp43 Antibodies in a Patient with Disseminated Paracoccidioidomycosis [PDF]
Journal of Clinical Microbiology, 2005 ABSTRACT Serological tests are frequently used to diagnosis paracoccidioidomycosis. A glycoprotein of 43 kDa is considered to be the main diagnostic antigen, being recognized by virtually all patients' sera. A case of atypical serological response, consisting of a lack of detectable anti-gp43 antibodies, in a patient with disseminated ...
Mônica S M, Vidal +7 more
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Artificial Processive Catalytic Systems
Chemistry – A European Journal, Volume 30, Issue 25, May 2, 2024.A processive catalyst undergoes several rounds of catalysis before it is released from the substrate. The drawing shows possible ways (A–D) in which a synthetic catalyst can interact with the substrate to achieve processivity. Abstract Processive catalysts remain attached to a substrate and perform multiple rounds of catalysis.
Roeland J. M. Nolte +1 more
wiley +1 more source
New advances in the development of a vaccine against paracoccidiodomycosis.
Frontiers in Microbiology, 2012 Paracoccidioidomycosis is an endemic Latin American mycosis caused by Paracoccidioides brasiliensis and also by the recently described P. lutzii. The systemic mycosis is the 10th leading cause of death due to infectious diseases in Brazil. As published,
Luiz R R. Travassos +1 more
doaj +1 more source
Dendritic cells transfected with scFv from Mab 7.B12 mimicking original antigen gp43 induces protection against experimental Paracoccidioidomycosis. [PDF]
PLoS ONE, 2011 Paracoccidioidomycosis (PCM), endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis (P. brasiliensis), which primarily attacks lung tissue.
Karen S Ferreira +6 more
doaj +1 more source
Microbes and Infection, 2012 Paracoccidioidomycosis is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis. Its major antigen is a 43 kDa glycoprotein whose peptides embody different functions: P10 peptide, a T-cell epitope, induces protective response while P4 and P23 peptides inhibit both, macrophage functions and inflammatory reaction ...
Konno, Fabiana T.C. +7 more
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Detection of Paracoccidioides brasiliensis gp43 Gene in Sputa by Loop‐Mediated Isothermal Amplification Method [PDF]
Journal of Clinical Laboratory Analysis, 2009 AbstractThe fungus Paracoccidioides brasiliensis is the pathogen of paracoccidioidomycosis (PCM), a systemic mycosis prevalent in Latin America. The loop‐mediated isothermal amplification method (LAMP) was used in this study to detect the presence of P. brasiliensis in sputa samples from patients with chronic PCM, suspected PCM, and a negative control.
B T, Tatibana +8 more
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Evidence for positive selection in putative virulence factors within the Paracoccidioides brasiliensis species complex. [PDF]
PLoS Neglected Tropical Diseases, 2008 Paracoccidioides brasiliensis is a dimorphic fungus that is the causative agent of paracoccidioidomycosis, the most important prevalent systemic mycosis in Latin America. Recently, the existence of three genetically isolated groups in P. brasiliensis was
Daniel R Matute +3 more
doaj +1 more source
Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis [PDF]
Infection and Immunity, 1994 Extracellular matrix protein laminin binds specifically to yeast forms of Paracoccidioides brasiliensis and enhances adhesion of the fungus to the surface of epithelial Madin-Darby canine kidney cells in vitro. Immunoblotting of fungal extracts showed that the gp43 glycoprotein is responsible for adhesion.
Vicentini, A. P. +6 more
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Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats
Revista da Sociedade Brasileira de Medicina Tropical, 2019 INTRODUCTION: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats ...
Eduardo Alexandre Loth +5 more
doaj +1 more source
Diagnosis of paracoccidioidomycosis by dot immunobinding assay for antibody detection using the purified and specific antigen gp43 [PDF]
Journal of Clinical Microbiology, 1994 The dot immunobinding assay, a rapid, visually read test, was adapted for serodiagnosis and follow-up of paracoccidioidomycosis (PCM). Purified gp43 antigen was tested before and after sodium metaperiodate treatment. To evaluate the assay, it was tested with sera from PCM, histoplasmosis, Jorge Lobo's disease, aspergillosis, candidiasis, and ...
C P, Taborda, Z P, Camargo
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