Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection. [PDF]
PLoS Neglected Tropical Diseases, 2017 Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes.
Rodrigo Assunção Holanda +10 more
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Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43 [PDF]
Medical Mycology, 2017 Apoptosis is considered an escape mechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process.
Bernardi, Thais +12 more
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Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana. [PDF]
PLoS Neglected Tropical Diseases, 2019 INTRODUCTION:The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species.
Priscila Marques de Macedo +5 more
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Polymorphism in the Gene Coding for the Immunodominant Antigen gp43 from the Pathogenic Fungus Paracoccidioides brasiliensis [PDF]
Journal of Clinical Microbiology, 2000 ABSTRACT The gp43 glycoprotein is an immune-dominant antigen in patients with paracoccidioidomycosis (PCM). It is protective against murine PCM and is a putative virulence factor. The gp43 gene of Paracoccidioides brasiliensis B-339 is located in a 1,329-bp DNA fragment that includes two exons, a 78-bp ...
F V, Morais +4 more
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Semina: Ciências Agrárias, 2009 Paracoccidioidomycosis, caused by the dimorphic fungus Paracoccidioides brasiliensis, is the most prevalent human systemic mycosis in Latin America. Paracoccidioidomycosis affects mainly male rural workers, causing granulomatous lesions in organs such as
Mario Augusto Ono +4 more
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Detection of Circulating gp43 Antigen in Serum, Cerebrospinal Fluid, and Bronchoalveolar Lavage Fluid of Patients with Paracoccidioidomycosis [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACT Paracoccidioidomycosis (PCM) is an important systemic fungal disease, particularly among individuals living and working in rural areas of endemicity in Latin America, who, without antifungal therapy, may develop fatal acute or chronic infection. For such patients, the detection of antibody responses by immunodiffusion is
Silvia Helena, Marques da Silva +5 more
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Revista do Instituto de Medicina Tropical de São Paulo, 2018 Although colony-forming unit (CFU) counting is widely used to quantify fungal load in tissue from animal experimentally infected with Paracoccidioides brasiliensis, several technical disadvantages have been described.
Marcelo Vieira Costa +5 more
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Acute juvenile Paracoccidioidomycosis: A 9-year cohort study in the endemic area of Rio de Janeiro, Brazil. [PDF]
PLoS Neglected Tropical Diseases, 2017 BACKGROUND:Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the genus Paracoccidioides. It is the most important systemic mycosis in Latin America and the leading cause of hospitalizations and death among them in
Priscila Marques de Macedo +9 more
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Paracoccidioides brasiliensis infection in dogs from Western Brazilian Amazon
Pesquisa Veterinária Brasileira, 2012 The objective of the study was to evaluate Paracoccidioides brasiliensis infection in urban dogs from the municipality of Monte Negro, Rondonia, Western Brazilian Amazon.
Andréia C. Corte +7 more
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Antifungal and antitumor models of bioactive protective peptides
Anais da Academia Brasileira de Ciências, 2009 Peptides are remarkably reactive molecules produced by a great variety of species and able to display a number of functions in uni-and multicellular organisms as mediators, agonists and regulating substances. Some of them exert cytotoxic effects on cells
Elaine G. Rodrigues +3 more
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