Results 251 to 260 of about 113,722 (335)
Engineering GPCR signaling pathways with RASSLs
, 2008 Bruce R. Conklin +13 more
openalex +2 more sources
Deep learning in GPCR drug discovery: benchmarking the path to accurate peptide binding. [PDF]
Brief BioinformHoegen Dijkhof LR +4 more
europepmc +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
The FEBS Journal, EarlyView.The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz +3 more
wiley +1 more source
Enhancing binding affinity predictions through efficient sampling with a re-engineered BAR method: a test on GPCR targets. [PDF]
Chem SciKim M, Jeong J, Kim D, Lee S, Cho AE.
europepmc +1 more source
The FEBS Journal, EarlyView.Heterotrimeric (αβγ) G proteins are usually inactivated by regulators of G protein signaling (RGS) proteins, but Gαs is an exception. Comparative structural analysis identified unique Gαs structural elements that may interfere with RGS binding. Mutagenesis and biochemical assays showed that three residues in the Gαs GTPase domain are both necessary and
Sabreen Higazy‐Mreih +4 more
wiley +1 more source
Elucidation of signaling and functional activities of an orphan GPCR, GPR81
, 2008 Hongfei Ge +8 more
openalex +1 more source
Deciphering complexity of GPCR signaling and modulation: implications and perspectives for drug discovery. [PDF]
Clin Sci (Lond)Costa-Neto CM, Parreiras-E-Silva LT.
europepmc +1 more source