Results 251 to 260 of about 92,511 (354)

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Biased agonism: An emerging paradigm in GPCR drug discovery

, 2015
Zoran Ranković, Tarsis F. Brust, Laura Bohn   +2 more
openalex   +2 more sources

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

HCAR2 is a novel receptor for heme. [PDF]

Blood Adv
Grunenwald A, Peliconi J, Zarantonello A, Dimitrov JD, Roumenina LT, Merle NS.   +5 more
europepmc   +1 more source

Class-IA Phosphoinositide 3-Kinase p110^|^beta; Triggers GPCR-Induced Superoxide Production in p110^|^gamma;-Deficient Murine Neutrophils

, 2012
Kiyomi Nigorikawa, Kaoru Hazeki, Takashi Kumazawa, Y. Itoh, Megumi Hoshi, Osamu Hazeki   +5 more
openalex   +2 more sources

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. [PDF]

Comput Struct Biotechnol J
Jelinek HF, Johnson MP, Khan FB, Elgendi M, Ayoub MA.   +4 more
europepmc   +1 more source

Integrative genomic analyses on GLI1: Positive regulation of GLI1 by Hedgehog-GLI, TGFβ-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals

, 2009
Katoh
openalex   +2 more sources

Synbiotic Nutraceutical Mitigates Gestational Diabetes Effects and Cardiovascular Dysfunction in Rat Offspring

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Maternal supplementation with a synbiotic nutraceutical consisting of jabuticaba peel and Limosilactobacillus fermentum strains during gestational diabetes mellitus (GDM) induces targeted shifts in gut microbial structure and attenuates systemic inflammatory signaling.
Deborah Emanuelle de Albuquerque Lemos, Evandro Leite de Souza, Micaelle Oliveira de Luna Freire, Jaielison Yandro Pereira da Silva, Paulo César Trindade da Costa, Josiane de Campos Cruz, Alisson Macário de Oliveira, João Felipe Mota, José Luiz de Brito Alves   +8 more
wiley   +1 more source

G protein-coupled receptor-mediated renal fibrosis: a key focus on kidney disease drug development. [PDF]

Front Pharmacol
Wang H, Yang M, Liu X, Fan J, Wang C.
europepmc   +1 more source