Results 251 to 260 of about 92,178 (306)

Ligand-specific activation trajectories dictate GPCR signalling in cells. [PDF]

Nature
Thomas R, Jacoby PS, De Faveri C, Derieux C, Liebing AD, Melkes B, Martini HJ, Bermúdez M, Stäubert C, Lohse MJ, Coin I, Bock A.   +11 more
europepmc   +1 more source

Unanchored K63-linked polyubiquitin chains: a novel second messenger involved in G protein-coupled receptors early signaling events. [PDF]

Cell Commun Signal
Doyon P, El-Mortada D, Roy J, El-Mortada F, Dô F, Gravel SP, Servant MJ.   +6 more
europepmc   +1 more source

Tuning the Response of GPCR-Based Yeast Sensors Using Fluorescent Reporters. [PDF]

ACS Synth Biol
Langevin R, Martin-Downey M, Patel A, Archer H, Davila Severiano SJ, Peralta-Yahya P.   +5 more
europepmc   +1 more source

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR-Gα interface. [PDF]

Elife
Mohanty SK, Mittal A, Farooqi N, Gaur A, Duari S, Solanki S, Sharma AK, Arora S, Kumar S, Gautam V, Dixit NK, Subramanian K, Ghosh TS, Sengupta D, Gupta SK, Murugan AN, Sharma D, Ahuja G.   +17 more
europepmc   +1 more source

A chemogenetic approach for temporal and cell-specific activation of endogenous GPCRs in vivo. [PDF]

Proc Natl Acad Sci U S A
Shingles G, Pang Q, Weng J, Singer R, Babar W, Shen J, Vazquez-Rivera L, Chen Y, Li P, Wang W.   +9 more
europepmc   +1 more source

Trends in GPCR drug discovery: new agents, targets and indications

Nature Reviews Drug Discovery, 2017
Alexander S Hauser, Misty M Attwood, Mathias Rask-Andersen   +2 more
exaly   +2 more sources

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Cell, 2022
SUMMARY Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins, while others interact only transiently; this difference affects GPCR ...
John Janetzko, Brian K Kobilka
exaly   +2 more sources

GPCR Dynamics: Structures in Motion

Chemical Reviews, 2017
Naomi R Latorraca, A J Venkatakrishnan
exaly   +2 more sources