Results 291 to 300 of about 142,523 (351)

Reducing Foetal Bovine Serum Culture Conditions does not affect GPCR Signalling

Pearce A, Collins M, Dexter A, Saji A, Sisk CM, Taylor E, Yu Y, Wills E, Ladds G.   +8 more
europepmc   +1 more source

AI meets physics in computational structure-based drug discovery for GPCRs. [PDF]

NPJ Drug Discov
Michino M, Vendome J, Kufareva I.
europepmc   +1 more source

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, EarlyView.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source

Stabilized D₂R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes. [PDF]

Nat Commun
Sharrocks KL, Fanelli F, Liu Y, Milner AJ, Yining W, Byrne B, Hanyaloglu AC.   +6 more
europepmc   +1 more source

Physicochemical properties of GPCR amino acid sequences for understanding GPCR-G-protein coupling

, 2008
Ganga D. Ghimire, Hideki Tanizawa, Masashi Sonoyama, Shigeki Mitaku   +3 more
openalex   +2 more sources

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Structural insights into GPCR signaling activated by peptide ligands: from molecular mechanism to therapeutic application. [PDF]

Exp Mol Med
Kim J, Kim J, Choi C, Bae J, Choi HJ.
europepmc   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

EnGCI: enhancing GPCR-compound interaction prediction via large molecular models and KAN network. [PDF]

BMC Biol
Liu W, Li X, Hang B, Wang P.
europepmc   +1 more source

Targeting the Secretin Receptor in Macrophages Attenuates Silica‐Induced Pulmonary Fibrosis

Cell Proliferation, EarlyView.
Targeting macrophage SCTR mitigates integrated profibrotic, inflammatory, ER stress, and senescent pathways, preserving lung function and revealing a novel therapeutic strategy for silicosis.
Yaqian Li, Tian Li, Fuyu Jin, Shupeng Liu, Dingjie Xu, Zhongqiu Wei, Xuemin Gao, Wenchen Cai, Na Mao, Fang Yang, Haibo Zhang, Yiwei Shi, Hong Xu   +12 more
wiley   +1 more source