Results 291 to 300 of about 83,092 (356)

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

A progressive fine-tuning framework with dynamic parameter selection for low-resource peptide-GPCR interaction prediction. [PDF]

Brief Bioinform
Liu M, Xu J, Liu J.
europepmc   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway. [PDF]

Nat Struct Mol Biol
Steiner WP, Iverson N, Liu G, Venkatakrishnan V, Wu J, Stepniewski TM, Michaelson Z, Bröckel JW, Zhu JF, Bruystens JGH, Lee A, Nelson I, Bertinetti D, Arveseth CD, Tan G, Spaltenstein P, Xu J, Hüttenhain R, Kay MS, Herberg FW, Cao E, Selent J, Anand GS, Dunbrack RL, Taylor SS, Myers BR.   +25 more
europepmc   +1 more source

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero, Niall Prendiville, Tatiana Cazorla, Maria Baena‐Nuevo, Röhm Sandra, Emilio Camafeita, Stefan Knapp, Patricia Alfonso   +7 more
wiley   +1 more source

GPCR-selective effects of endocytosis on cellular signaling through the cAMP/PKA cascade. [PDF]

J Biol Chem
Blythe EE, Fagan RR, von Zastrow M.
europepmc   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source

G Protein-Coupled Receptors in Irritable Bowel Syndrome: Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Zhu Z, Liu Z, He Y, He X, Zheng W, Jiang M.   +5 more
europepmc   +1 more source