Results 321 to 330 of about 113,722 (335)
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Science Signaling, 2011
The muscarinic acetylcholine receptor exhibits voltage-dependent gating currents that may enhance neurotransmitter release at cholinergic synapses.
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The muscarinic acetylcholine receptor exhibits voltage-dependent gating currents that may enhance neurotransmitter release at cholinergic synapses.
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Journal of the American Chemical Society, 2005
This paper describes G-protein-coupled receptor (GPCR) microarrays on porous glass substrates and functional assays based on the binding of a europium-labeled GTP analogue. The porous glass slides were made by casting a glass frit on impermeable glass slides and then coating with gamma-aminopropyl silane (GAPS). The emitted fluorescence was captured on
John C. Mauro +18 more
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This paper describes G-protein-coupled receptor (GPCR) microarrays on porous glass substrates and functional assays based on the binding of a europium-labeled GTP analogue. The porous glass slides were made by casting a glass frit on impermeable glass slides and then coating with gamma-aminopropyl silane (GAPS). The emitted fluorescence was captured on
John C. Mauro +18 more
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2010
There are a total of 33 members of adhesion G protein-coupled receptors (GPCRs) in humans and 30 members in mice and rats. More than half of these receptors are expressed in the central nervous system (CNS), indicating their possible roles in the development and function of the CNS.
Natalie Strokes, Xianhua Piao
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There are a total of 33 members of adhesion G protein-coupled receptors (GPCRs) in humans and 30 members in mice and rats. More than half of these receptors are expressed in the central nervous system (CNS), indicating their possible roles in the development and function of the CNS.
Natalie Strokes, Xianhua Piao
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GPCR & Company: Databases and Servers for GPCRs and Interacting Partners
2013G-protein-coupled receptors (GPCRs) are a large superfamily of membrane receptors that are involved in a wide range of signaling pathways. To fulfill their tasks, GPCRs interact with a variety of partners, including small molecules, lipids and proteins. They are accompanied by different proteins during all phases of their life cycle.
Masha Y. Niv, Noga Kowalsman
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Current Opinion in Structural Biology, 2019
Molecular switches in GPCRs enable passing the signal from the agonist binding site, usually located close to the extracellular surface, to the intracellular part of the receptor. The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adjacent residues which provide the signal to
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Molecular switches in GPCRs enable passing the signal from the agonist binding site, usually located close to the extracellular surface, to the intracellular part of the receptor. The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adjacent residues which provide the signal to
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2009
Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used ...
Patrick M. Sexton +6 more
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Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used ...
Patrick M. Sexton +6 more
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Trends in Biotechnology, 2005
G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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Orphan GPCRs and their ligands
Pharmacology & Therapeutics, 2006Due to their diversity, G-protein-coupled receptors (GPCRs) are major regulators of intercellular interactions. They exert their actions by being activated by a vast array of natural ligands, referred to in this article as "transmitters". Yet each GPCR is highly selective in its ligand recognition.
Rainer K. Reinscheid +4 more
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Nature Methods, 2010
Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.
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Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.
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2010
Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily
Simon Yona, Hsi-Hsien Lin, Martin Stacey
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Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily
Simon Yona, Hsi-Hsien Lin, Martin Stacey
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