Results 321 to 330 of about 83,092 (356)
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Trends in Biotechnology, 2005
G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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Privileged Structures in GPCRs
2007Certain kinds of ligand substructures recur frequently in pharmacologically successful synthetic compounds. For this reason they are called privileged structures. In seeking an explanation for this phenomenon, it is observed that the privileged structure represents a generic substructure that matches commonly recurring conserved structural motifs in ...
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Nature Methods, 2010
Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.
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Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.
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Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
Cell, 2022John Janetzko, Brian K Kobilka
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Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling
Cell, 2017Marian Kalocsay +2 more
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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Molecular Cell, 2020Yi-Lynn Liang +2 more
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