Results 181 to 190 of about 22,632 (211)

Expression of estradiol receptor, GPR30, in bovine anterior pituitary and effects of GPR30 agonist on GnRH-induced LH secretion

Animal Reproduction Science, 2013
G-protein - coupled receptor 30 (GPR30) is an estradiol receptor located on the plasma membrane, and it initiates several rapid, non-genomic signaling events. GPR30 has recently been identified in rat anterior pituitary (AP); however, little is known about the role of GPR30 in controlling luteinizing hormone (LH) secretion from gonadotropes in animals.
Faidiban O, Rudolf, Hiroya, Kadokawa
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Activation of the GPR30 Receptor Promotes Lordosis in Female Mice

Neuroendocrinology, 2014
<b><i>Background/Aims:</i></b> Estrogens are important effectors of reproduction and are critical for upregulating female reproductive behavior or lordosis in females. In addition to the importance of transcriptional regulation of genes by 17β-estradiol-bound estrogen receptors (ER), extranuclear signal transduction cascades ...
Divya, Anchan, Amber, Gafur, Kazuhiro, Sano, Sonoko, Ogawa, Nandini, Vasudevan   +4 more
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GPR30: a novel therapeutic target in estrogen-related disease

Trends in Pharmacological Sciences, 2008
Estrogen is a crucial hormone in human physiology that regulates a multitude of biological processes. It is also an important target in many diseases such as cancer and skeletal, neurological and immunological conditions. The actions of estrogen have traditionally been ascribed to one of two closely related classical nuclear hormone receptors, ERalpha ...
Eric R, Prossnitz, Larry A, Sklar, Tudor I, Oprea, Jeffrey B, Arterburn   +3 more
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MicroRNA‐2861 and microRNA‐5115 regulates myocardial ischemia–reperfusion injury through the GPR30/mTOR signaling pathway by binding to GPR30

Journal of Cellular Physiology, 2020
AbstractMyocardial ischemia–reperfusion (I/R) injury, a major contributor to morbidity and mortality, represents a combination of intrinsic cellular response to ischemia and the extrinsic acute inflammatory response. In the present study, microarray analysis of GSE67308 and GSE50885 identified differentially expressed GPR30 and upstream regulatory miR ...
Lijie Zhu, Qingman Li, Qingmin Li, Datun Qi, Chuanyu Gao, Honghui Yang   +5 more
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Synthetic Estrogen Derivatives Demonstrate the Functionality of Intracellular GPR30

ACS Chemical Biology, 2007
Estrogen mediates its effects through multiple cellular receptors. In addition to the classical nuclear estrogen receptors (ERalpha and ERbeta), estrogen also signals through the seven-transmembrane G-protein-coupled receptor (GPCR) GPR30. Although estrogen is a cell-permeable ligand, it is often assumed that all GPCRs function solely as cell surface ...
Chetana M, Revankar, Hugh D, Mitchell, Angela S, Field, Ritwik, Burai, Cesear, Corona, Chinnasamy, Ramesh, Larry A, Sklar, Jeffrey B, Arterburn, Eric R, Prossnitz   +8 more
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Virtual and biomolecular screening converge on a selective agonist for GPR30

Nature Chemical Biology, 2006
Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor alpha (ERalpha) and more recently ERbeta, members of the soluble, nuclear ligand-activated family of transcription factors.
Cristian G, Bologa, Chetana M, Revankar, Susan M, Young, Bruce S, Edwards, Jeffrey B, Arterburn, Alexander S, Kiselyov, Matthew A, Parker, Sergey E, Tkachenko, Nikolay P, Savchuck, Larry A, Sklar, Tudor I, Oprea, Eric R, Prossnitz   +11 more
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Calmodulin regulates GPER/GPR30‐mediated signaling

The FASEB Journal, 2016
The G protein‐coupled estrogen receptor 1 (GPER/GPR30) was recently identified as a novel receptor for estrogen, and has been demonstrated to be involved in numerous processes in various organ systems. However, its regulatory inputs are not entirely understood. Calmodulin (CaM) is the ubiquitous transducer of Ca
Vahe Matnishian, Jake Jasurda, Phuong Tran, Mark VerMeer, QUANG‐KIM TRAN   +4 more
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GPR30 Does Not Mediate Estrogenic Responses in Reproductive Organs in Mice

Biology of Reproduction, 2009
The G protein-coupled receptor Gpr30 (Gper) was recently claimed to bind to estradiol and to activate cytoplasmic signal transduction pathways in response to estradiol. However, there are conflicting data regarding the role of Gpr30 as an estrogen receptor (ER): several laboratories were unable to demonstrate estradiol binding to GPR30 or estradiol ...
Christiane, Otto, Iris, Fuchs, Gunther, Kauselmann, Heidrun, Kern, Branko, Zevnik, Puk, Andreasen, Gilda, Schwarz, Helga, Altmann, Mario, Klewer, Michael, Schoor, Richardus, Vonk, Karl-Heinrich, Fritzemeier   +11 more
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GPR30 Signaling and Regulation in Breast Cancer

2011
Abstract : Estrogen plays a significant role in the progression of breast cancer, leading to increased growth of breast tumors. Until 2005, the classical estrogen receptor, ER , was believed to modulate the entirety of E2-dependent breast cancer growth.
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Mesothelin and GPR30 Staining Among a Spectrum of Pancreatic Epithelial Neoplasms

International Journal of Surgical Pathology, 2011
Introduction: Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology. Materials and Methods: Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions. Results: 24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (
Joseph P, Glass, Gulshan, Parasher, Hugo, Arias-Pulido, Rachel, Donohue, Eric R, Prossnitz, Lisa A, Cerilli   +5 more
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