Results 71 to 80 of about 3,347 (166)

Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

Journal of Neuroinflammation, 2018
Background Neuroinflammation plays a vital role in Alzheimer’s disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system, and they play essential roles in the maintenance of ...
Soraya Wilke Saliba, Hannah Jauch, Brahim Gargouri, Albrecht Keil, Thomas Hurrle, Nicole Volz, Florian Mohr, Mario van der Stelt, Stefan Bräse, Bernd L. Fiebich   +9 more
doaj   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal Myotubes

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
(a) C2C12 myoblasts were cultured and differentiated over 7 days until mature myotubes were formed. (b) Myotubes were treated with PEA (10 μM), IBU (100 μM) or VC for 36 h. Simultaneously, cells were incubated with D2O (deuterium oxide) for isotopic labeling.
Paige L. Cole, Connor A. Stead, Jatin G. Burniston, Daniel J. Owens   +3 more
wiley   +1 more source

GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

Heliyon
Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal.
Jinlong Zhang, Jie Yan, Shuyue Li, Qianqian Chen, Jiang Lin, Yilin Peng, Yuhang Liu, Binbin Wang, Xinrong Wei, Chen Sun, Shuliang Niu   +10 more
doaj   +1 more source

Lnc-ITM2C-1 and GPR55 Are Proviral Host Factors for Hepatitis C Virus

Viruses, 2019
Multiple host factors are known to play important roles in hepatitis C virus (HCV) replication, in immune responses induced by HCV infection, or in processes that facilitate virus escape from immune clearance, while yet only few studies examined the ...
Pan Hu, Jochen Wilhelm, Gesche K. Gerresheim, Lyudmila A. Shalamova, Michael Niepmann   +4 more
doaj   +1 more source

New blood brothers: the GPR55 and CB2 partnership [PDF]

Cell Research, 2011
Endocannabinoids are increasingly being recognized as key lipid-derived regulators of immune function 1. Although the peripheral cannabinoid type 2 receptor (CB2) is thought to orchestrate many of these actions, additional non-CB1/CB2-mediated effects of cannabinoids have been identified in immune cells 1, 2, where several orphan G protein-coupled ...
openaire   +3 more sources

GPR55 Inactivation Diminishes Splenic Responses and Improves Neurological Outcomes in the Mouse Ischemia/Reperfusion Stroke Model

Cells
Although strokes are frequent and severe, treatment options are scarce. Plasminogen activators, the only FDA-approved agents for clot treatment (tissue plasminogen activators (tPAs)), are used in a limited patient group.
Sachin Gajghate, Hongbo Li, Slava Rom
doaj   +1 more source

Discovery and pharmacological evaluation of a novel series of chromenopyrazole-based GPR55 modulators in an androgen-driven model of female metabolic dysfunction

European Journal of Medicinal Chemistry Reports
GPR55 is a lipid-responsive G-protein-coupled receptor implicated in metabolic regulation, but its characterization has been limited by the poor selectivity and pathway bias of classical ligands.
Francisco J. Ponce-Díaz, Francisco Ruiz-Pino, Aitor Herraiz, Beatriz Romero, Laura Cerero-Tejero, Adela García-Martín, Simon Porzio-Gonzalez, Paula Morales, Miguel A. Sánchez-Garrido, Marina Pulido, Nadine Jagerovic, Manuel Tena-Sempere, Eduardo Muñoz   +12 more
doaj   +1 more source

Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures

Neural Plasticity, 2015
Microglial activation is a polarized process divided into potentially neuroprotective phenotype M2 and neurotoxic phenotype M1, predominant during chronic neuroinflammation.
Natalia Malek, Katarzyna Popiolek-Barczyk, Joanna Mika, Barbara Przewlocka, Katarzyna Starowicz   +4 more
doaj   +1 more source

DEVELOPMENT OF NOVEL GPR55 LIGANDS AND GPR55/CB2R MULTITARGET MODULATORS FOR NEURODEGENERATIVE DISEASES

, 2023
Neurodegenerative diseases lead to the loss of specific neuronal populations, with the consequent development of several impairments in cognitive functions, movement and memory. [1] Despite specific pathological triggers, all these disorders are characterized by a common microglia-mediated neuroinflammation.
openaire   +2 more sources