Results 31 to 40 of about 48,780 (260)

GPX – Gardens Point XML IR at INEX 2005 [PDF]

, 2006
The INEX 2005 evaluation consisted of numerous tasks that required different approaches. In this paper we described the approach that we adopted to satisfy the requirements of all the tasks, CAS and CO, in Thorough, Focused, and Fetch Browse mode, using the same underlying system The retrieval approach is based on the construction of a collection sub ...
openaire   +4 more sources

The role of malonic acid derivate in the modulation of metabolic pathways in the kidneys during chronic heart failure

Разработка и регистрация лекарственных средств
Introduction. Chronic heart failure (CHF) often leads to progressive renal dysfunction; however, pharmacological protection strategies aimed at correcting metabolic and oxidative disturbances in renal tissue remain underdeveloped.
A. Yu. Grishina, D. Yu. Ivkin, A. A. Karpov, A. I. Bolshukhina, A. R. Muslimov, A. S. Ivanov, O. V. Buyuklinskaya   +6 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The Effect of Eight Weeks of Aerobic Training on MDA, TAC, GPX, and SOD in Heart Tissue of Wistar Rats [PDF]

ورزش و علوم زیست حرکتی
Introduction and Purpose: Cardiovascular disease is one of the main causes of death in the world. The present study aimed to determine the effect of eight weeks of aerobic exercise on the levels of MDA, TAC, GPX, and SOD in the heart tissue of healthy ...
Elaheh Piralaiy, Badrkhan Rashwan Ismael, Gholamreza Hamidiyan   +2 more
doaj   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Determination of Reactive Oxygen Species and Some Antioxidants in Iraqi Patients with Myelodysplastic Syndrome

Medical Journal of Babylon
Background: A diverse set of clonal hematopoietic illnesses known as myelodysplastic syndrome (MDS) have decreased survival rates, risk factors for leukemia transformation, and a variety of clinical manifestations. This makes the clinical relevance of an
Wid Abdulkhaleq Abd Zaid, Sawsan Hassan Kadhum, Sarah Abdulkareem Mukheef, Ayat Raheem Khalf, Walaa Salih Hassan, Ali Hmood Al-Saadi   +5 more
doaj   +1 more source

Assessing Antioxidant Enzyme Activity in Zebrafish Larvae Treated with Diosgenin and Doxorubicin [PDF]

E3S Web of Conferences
In this research, zebrafish larvae models were employed to evaluate the activity of antioxidant enzymes—GSH, GPX, and GST—in response to treatments with doxorubicin and a novel drug, diosgenin.
Logeswari G., Praveen Kumar I.
doaj   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Biochemical and physiological responses of Pinus eldarica and Platanus orientalis leaves to air pollution in Tehran [PDF]

مجله جنگل ایران, 2017
Air pollution has advers impacts on human beings, animals and plants. Leves and flowers are the most sensetive part of plants which are used as bioindicator under air pollution stress.
Esmaeil Khosropour, Pedram Attarod, انوشیروان شیروانی, ویلما بایرام زاده, لیلا حکیمی   +4 more
doaj