Results 101 to 110 of about 40,571 (376)

Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1 [PDF]

, 2015
Functional SNPs selected for the study. Table S2. Restriction fragment analysis for BRCA1 mutations. Table S3. Oxidative stress parameters in breast cancer cases according to treatment.
Agnieszka Bukowska, Beata Peplonska, Edyta Reszka, Edyta Wieczorek, Ewa Jablonska, Jolanta Gromadzinska, Magdalena B. Krol, Michal Galicki, Oskar Zambrano Quispe, Peter Gresner, Wojciech Fendler, Wojciech Wasowicz, Zbigniew Morawiec   +12 more
core   +2 more sources

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Journal of experimental & clinical cancer research : CR
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to ...
Ya-Tiao Qiao, Meng Su, Huifang Zhao, Huanle Liu, Chenxi Wang, Xintong Dai, Lingling Liu, Guangju Liu, Huanran Sun, Mingming Sun, Jiyan Wang, Zhen Li, Jun Fan, Quan Zhang, Chunshen Li, Fangmin Situ, Jun Xue, Zhenghu Jia, Chunze Zhang, Shuai Zhang, Changliang Shan   +20 more
semanticscholar   +1 more source

Noscapine derivative 428 suppresses ferroptosis through targeting GPX4

Redox Biology
Inhibiting ferroptosis represents a promising strategy to combat ferroptosis-related diseases. Here we show that 428, a selenide-containing noscapine derivative, effectively inhibits ferroptosis in various cell lines by enhancing the stability and activity of GPX4. TRIM41 was identified as a novel E3 ubiquitin ligase of GPX4 and 428 was demonstrated to
Youping Zhang, Haoliang Shi, Yingying Wang, Wanting Liu, Guanyi Li, Defeng Li, Wenxuan Wu, Yunzhao Wu, Ziwei Zhang, Yanjie Ji, Chujiao Zhu, Wenhui Bai, Hu Lei, Hanzhang Xu, Hua Zhong, Baohui Han, Li Yang, Ligen Liu, Wei Wang, Yaxue Zhao, Yongqiang Zhang, Yingli Wu   +21 more
openaire   +3 more sources

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma. [PDF]

, 2017
Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation ...
Fanzani, Alessandro, Poli, Maura
core   +1 more source

α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway

Cellular & Molecular Biology Letters
Osteoarthritis (OA) is the most common degenerative joint disorder that causes disability in aged individuals, caused by functional and structural alterations of the knee joint.
Rong-Rong He, Yuchi Wei, Zeyu Peng, Jie Yang, Zhenwei Zhou, Ailin Li, Yongji Wu, Mingyue Wang, Xiangyan Li, Daqing Zhao, Zhonghua Liu, Haisi Dong, Xiangyang Leng   +12 more
semanticscholar   +1 more source

The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression

Redox Biology
Ferroptosis, a form of oxidative cell death mediated by lipid peroxidation, is strictly regulated by glutathione peroxidase 4 (GPX4). Knockout of Gpx4 results in embryonic lethality, highlighting its essential role in development. In vitro, mouse embryonic stem cells (mESCs), which represent the naïve pluripotent state, require β-mercaptoethanol (bME ...
Seokwoo Park, Mihn Jeong Park, Eun-Ji Kwon, Ji-Young Oh, Yeon-Joon Chu, Han Sun Kim, Sunghyouk Park, Tae Ha Kim, Sung Won Kwon, Yon Su Kim, Hyuk-Jin Cha   +10 more
openaire   +3 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice [PDF]

, 2017
Nonalcoholic steatohepatitis is one of the leading causes of liver disease. Dietary factors determine the clinical presentation of steatohepatitis and can influence the progression of related diseases. Cholesterol has emerged as a critical player in the
Baulies, Anna, Fernández-Checa, José C., García-Ruiz, Carmen, Gómez-Quiroz, Luís Enrique, Nuño-Lámbarri, Natalia   +4 more
core   +1 more source

A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4

Theranostics
Background: Ferroptosis, a recently unveiled iron-dependent form of cellular demise, has emerged as a pivotal process contributing to the pathology of Alzheimer's Disease (AD).
Yuan-Yuan Yong, Lu Yan, Jing Wei, Chi Feng, Lu Yu, Jianming Wu, Minsong Guo, Dongsheng Fan, Chong-Lin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu   +11 more
semanticscholar   +1 more source