Results 81 to 90 of about 26,946 (260)

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway

Drug Design, Development and Therapy
An Zhou,1– 3 Hao-Yinghua Feng,4 Chu-Ning Fan,3 Jun Wang,3 Zhong-Yu Yuan,3 Guang-Hui Xu,5 Cheng-Fu Li,6 Wei-Feng Huang,1 Li-Tao Yi3,7,8 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine,
Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT   +8 more
doaj  

Triple-negative breast cancer and ferroptosis: expression profiling of key regulatory genes

Archives of Medical Science
Introduction Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
Serife E. Antmen, Cem Yalaza, Ferah Tuncel, Mustafa Berkesoglu, Sema Erden Erturk, Necmiye Canacankatan   +5 more
doaj   +1 more source

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

Molecular Metabolism, 2015
Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear.
Lalage A. Katunga, Preeti Gudimella, Jimmy T. Efird, Scott Abernathy, Taylor A. Mattox, Cherese Beatty, Timothy M. Darden, Kathleen A. Thayne, Hazaim Alwair, Alan P. Kypson, Jitka A. Virag, Ethan J. Anderson   +11 more
doaj   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Progress on the mechanisms of ferroptosis in diabetic retinopathy

Yanke Xuebao
Ferroptosis represents an iron-dependent form of programmed cell death, marked by the abnormal accumulation of lipid peroxides and a disruption in redox homeostasis.
PAN Yanchao, PENG Chao
doaj   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis

Nature Communications
S-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on cysteine 66.
Bin Huang, Hui Wang, Shuo Liu, Meng Hao, Dan Luo, Yi Zhou, Ying Huang, Yong Nian, Lei Zhang, Bo Chu, Chengqian Yin   +10 more
openaire   +3 more sources

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

GPx4 is bound to peroxidized membranes by a hydrophobic anchor

Journal of Molecular Biology
Ferroptosis is a form of cell death discovered in recent years, induced by excessive peroxidation of phospholipids. Glutathione peroxidase 4 (GPx4) is an intracellular enzyme that can repair the peroxidized phospholipids on membranes, thus regulating ferroptosis.
Hu, Qingyang, You, Hantian, Li, Kenan, Lai, Luhua, Song, Chen   +4 more
openaire   +3 more sources