Results 71 to 80 of about 33,929 (300)

GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

BMC Cancer, 2022
Background Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail.
Sitian Wei, Zhicheng Yu, Rui Shi, Lanfen An, Qi Zhang, Qian Zhang, Tangansu Zhang, Jun Zhang, Hongbo Wang   +8 more
doaj   +1 more source

The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. [PDF]

, 2017
EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown.
Atkin, Naomi, Chen, Yumay, Gau, Alex, Giedzinski, Erich, Hu, Yuanjie, Lee, Nathan, Limoli, Charles, Linskey, Mark E, Ly, Khang Chi, Pan, Francine, Qiao, Jiao, Ru, Ning, Siegel, Eric R, Tran, Katherine, Wang, Ping, Yu, Liping, Zhou, Yi-Hong   +16 more
core   +1 more source

The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression

Redox Biology
Ferroptosis, a form of oxidative cell death mediated by lipid peroxidation, is strictly regulated by glutathione peroxidase 4 (GPX4). Knockout of Gpx4 results in embryonic lethality, highlighting its essential role in development. In vitro, mouse embryonic stem cells (mESCs), which represent the naïve pluripotent state, require β-mercaptoethanol (bME ...
Seokwoo Park, Mihn Jeong Park, Eun-Ji Kwon, Ji-Young Oh, Yeon-Joon Chu, Han Sun Kim, Sunghyouk Park, Tae Ha Kim, Sung Won Kwon, Yon Su Kim, Hyuk-Jin Cha   +10 more
openaire   +3 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury

Journal of Integrative Neuroscience
Background: It has been reported that ferroptosis participates in the pathophysiological mechanism of spinal cord injury (SCI). Our preliminary experiments verified that dendrobium nobile polysaccharide (DNP) improved the behavioral function of SCI rats.
Jian Huang, Jianghong Luo, Ying Huang, Linghong Wang, Haibing Zhu, Zhengnan Li, Jianping Chen   +6 more
doaj   +1 more source

Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina. [PDF]

PLoS ONE, 2015
The purpose of the present study was to investigate the role of glutathione peroxidase 4 (GPx4) in glutamate-induced oxytosis in the retina.For in vitro studies, an immortalized rat retinal precursor cell line R28 was used.
Osamu Sakai, Takatoshi Uchida, Murilo F Roggia, Hirotaka Imai, Takashi Ueta, Shiro Amano   +5 more
doaj   +1 more source

Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 [PDF]

, 2017
学位記番号 ...
Shintoku, Ryosuke, シントク, リョウスケ, 神徳, 亮介   +2 more
core  

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome [PDF]

, 2017
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (
Barriocanal-Casado, Eliana, Chaves-Serrano, Julio, Hidalgo-Gutierrez, Agustin, Hildebrandt, Tatjana M., Luna-Sanchez, Marta, Schuelke, Markus [u.a.]   +5 more
core   +4 more sources

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1 /GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science
Abstract The standard regimen of gemcitabine combined with cisplatin offers limited clinical benefits in the treatment of advanced intrahepatic cholangiocarcinoma (ICC) due to intrinsic or acquired resistance. Currently, effective biomarkers to predict and improve chemotherapy resistance in ICC are lacking.
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
openaire   +2 more sources