Results 71 to 80 of about 34,214 (293)

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib

Frontiers in Oncology, 2020
Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern. Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC cell growth. We investigated GPX4-mediated ferroptosis in gefitinib
Xiang Song, Xinzhao Wang, Zhaoyun Liu, Zhiyong Yu   +3 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury

Journal of Integrative Neuroscience
Background: It has been reported that ferroptosis participates in the pathophysiological mechanism of spinal cord injury (SCI). Our preliminary experiments verified that dendrobium nobile polysaccharide (DNP) improved the behavioral function of SCI rats.
Jian Huang, Jianghong Luo, Ying Huang, Linghong Wang, Haibing Zhu, Zhengnan Li, Jianping Chen   +6 more
doaj   +1 more source

RESPUESTA ANTIOXIDANTE DE GPx2 Y GPx4 ANTE HIPOXIA Y REOXIGENACIÓN DURANTE EL SILENCIAMIENTO DE p53 Y GPx4 EN EL CAMARÓN Litopenaeus vannamei [PDF]

, 2023
Las glutatión peroxidasas (GPx) son importantes enzimas antioxidantes. En vertebrados, existen ocho isoformas de la GPx con diferente distribución, especificidad de sustrato y funciones no canónicas.
PAULINA ESTRADA CARDENAS
core  

GPX4 Alleviates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting Ferroptosis

, 2022
Pharmacological therapy of diabetes mellitus-induced erectile dysfunction (DMED) is intractable owig to the poor response to phosphodiesterase type 5 inhibitors (PDE5i).
Hao Li, Taotao Sun, Wang, Jiaxin, Li, Hao, Xu, Wenchao, Wang, Shaogang, Wenchao Xu, Wang, Tao, Jiaxin Wang, Liu, Jihong, Shaogang Wang, Tao Wang, Sun, Taotao, Jihong Liu   +13 more
core   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

NeuroD1 directly binds to the GPX4 promoter and regulates its transcriptional activity.

, 2023
(A) NeuroD1 and GPX4 protein expression levels in NeuroD1-overexpressed HCC-LM3 cells treated with actinomycin D or cycloheximide, as determined using western blotting. (B) Schematic diagram of the predicted NeuroD1 binding sites on the GPX4 promoter. (C)
Wei Duan (101868), Zheng Wu (344022), Lingxian Wang (4634977), Shourong Wu (391683), Rendy Hosea (17697125), Cao Ruan (16627266), Ping Huang (30439), Jianting Zeng (17697128), Vivi Kasim (391682)   +8 more
core   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Fluorescent Turn-On Probes for Visualizing GPx4 Levels in Live Cells and Predicting Drug Sensitivity

, 2023
Glutathione peroxidase 4 (GPx4) is the membrane peroxidase in mammals that is essential for protecting cells against oxidative damage and critical for ferroptosis. However, no live cell probe is currently available to specifically label GPx4.
Meizhou Zhang (9924888), Yu Fu (16582), Meizhou Zhang, Hongmei Liu (129385), Longjie Li, Longjie Li (646597), Yu Fu, Huaibin Yu, Jinsheng Li (5964254), Fangrui Zhong (1903435), Fangrui Zhong, Hongmei Liu, Jinsheng Li, Huaibin Yu (4400155), Shuangshuang Wang (1889083), Yuzhou Wu, Zi’an Lin, Zi’an Lin (16321937), Shuangshuang Wang, Yuzhou Wu (1390366)   +19 more
core   +1 more source