Results 161 to 170 of about 29,098 (325)

Bioinformatics and Integrative Experimental Method to Identifying and Validating Co-Expressed Ferroptosis-Related Genes in OA Articular Cartilage and Synovium

Journal of Inflammation Research
Jinxin Ma,1,* Peng Yu,1,* Shang Ma,1,* Jinjin Li,1 Zhen Wang,1 Kunpeng Hu,1 Xinzhe Su,1 Bei Zhang,1 Shao Cheng,1– 3 Shangzeng Wang1– 3 1School of Osteopathy, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China ...
Ma J, Yu P, Ma S, Li J, Wang Z, Hu K, Su X, Zhang B, Cheng S, Wang S   +9 more
doaj  

DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis

Bone Research
Osteoporosis (OP) is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure and pathologically involving various forms of regulated bone cell death.
Binjia Ruan, Jian Dong, Fanhao Wei, Zhiqiang Huang, Bin Yang, Lijun Zhang, Chuling Li, Hui Dong, Wangsen Cao, Hongwei Wang, Yongxiang Wang   +10 more
doaj   +1 more source

Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status [PDF]

, 2010
It has been well known that free radicals have numerous detrimental effects in both in vitro and in vivo in biological systems because of their unavoidable and tremendous reactivity against biological macromolecules especially proteins, carbohydrates and
Sadi, Gökhan, Sadi, Özlem
core  

Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis

, 2022
Ya Zhang, Qifang Wu, Jian Liu, Zhongshan Zhang, Xiaojing Ma, Yaoyue Zhang, Jiawen Zhu, Ronald W. Thring, Mingjiang Wu, Yitian Gao, Haibin Tong   +10 more
openalex   +1 more source

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity

Advanced Science, EarlyView.
This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li, Hongrui Qin, Min Jiang, Hongjiang Wei, Hongyong Zhao, Ping Tang, Guangyu Jian, Henny C van der Mei, Tao Chen   +8 more
wiley   +1 more source

Impact of GPX1 null and GPX4 hemizygosity on plasma lipid profiles of mice fed a high fat diet

, 2007
Shikui Wang, Xin Gen Lei
openalex   +1 more source

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science, EarlyView.
In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
wiley   +1 more source

Reactive Oxygen Species Generated by 17β-estradiol Play a Role in the Up-regulation of GPX4 Protein in MCF-7 Breast Cancer Cells

, 2009
Sang-Han Lee, Hee Jeong Kim, Hyo Jin Kang, Yoon-Jin Lee, Hae-Seon Nam, Insoo Bae   +5 more
openalex   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4 [PDF]

, 2023
Lulin Cheng, Qingliu He, Bing Liu, Liang Chen, Fang Lv, Xuexiang Li, Yunxue Li, Chun‐Yu Liu, Yarong Song, Yifei Xing   +9 more
openalex   +1 more source