Results 181 to 190 of about 26,946 (260)

m6A‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

Allergy, EarlyView.
This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin, Baoai Han, Qiang Xie, Aikebaier Tuohuti, Weisong Cai, Peng Zhou, Jiahao Meng, Qiuyang Fu, Zuhong He, Xiong Chen   +9 more
wiley   +1 more source

Polyphyllin B induces ferroptosis in triple-negative breast cancer by inactivating NRF2. [PDF]

Front Pharmacol
Deng P, Zhu S, Wu Y, Fang Z, Zhang A, Zhang D, Hu X, Zhou X.   +7 more
europepmc   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury. [PDF]

J Inflamm Res
Tu L, Lu Y, Liu X, Shen X.
europepmc   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Cephaeline promotes ferroptosis in breast cancer via p53/SLC7A11/GPX4 axis. [PDF]

Daru
Li X, Yu J, Lin B, Gong Y.
europepmc   +1 more source

Proteomic Analysis Reveals AMPKα‐Mediated Antiandrogen Resistance via Ferroptosis Suppression in Prostate Cancer

Cancer Science, EarlyView.
Antiandrogen‐resistant prostate cancer cells acquire ferroptosis resistance through AMPKα activation and upregulation of ferroptosis suppressor pathways. This adaptive state creates a therapeutic vulnerability, as GPX4 inhibition, particularly in combination with AMPKα inhibition, effectively suppresses the growth of resistant cells.
Masaki Shiota, Tokiyoshi Tanegashima, Takahiko Hajime, Miho Ushijima, Shigehiro Tsukahara, Shohei Nagakawa, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto   +8 more
wiley   +1 more source

TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis. [PDF]

Cell Discov
Bai J, Geng D, Chen X, Li W, Wang X, Tian L, Han Y, Jin Z, Du M, Tang Y, Hu W, Zhu C, Zhang S, Zhao Z, Zhang R, Zhang X, Kang W, To K, Nomura S, Guo F, Jiao S, Xie Y, Zhou Z, Dong C, Li H, An L.   +25 more
europepmc   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

Intratumor <i>Lactobacillus</i> drives ferroptosis resistance via D-lactate-STAT3 K631 lactylation in esophageal squamous cell carcinoma. [PDF]

Gut Microbes
Wang D, Lu H, Li W, Li L, Xu X, Zhou H, Tao H, Li Y, Wei W, Wu K, Wang Y, Li R, Li Y, Yao W, Chen Y, Wang F, Ye L.   +16 more
europepmc   +1 more source