Results 171 to 180 of about 40,571 (376)

Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status [PDF]

, 2010
It has been well known that free radicals have numerous detrimental effects in both in vitro and in vivo in biological systems because of their unavoidable and tremendous reactivity against biological macromolecules especially proteins, carbohydrates and
Sadi, Gökhan, Sadi, Özlem
core  

LRRK2 regulates ferroptosis through the system Xc‐GSH–GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease

Journal of Cellular Physiology
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in the midbrain are its primary pathological manifestations.
Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiang-Dang Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui Lu   +10 more
semanticscholar   +1 more source

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Pain and Therapy
Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis ...
Shiwen Fan, Kaixin Wang, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Daan Fu, Xiangdong Chen   +7 more
openaire   +3 more sources

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Neural Precursor Cell-Expressed Developmentally Downregulated Protein 4 (NEDD4)-Mediated Ubiquitination of Glutathione Peroxidase 4 (GPX4): A Key Pathway in High-Glucose-Induced Ferroptosis in Corpus Cavernosum Smooth Muscle Cells

Biomolecules
Pharmacological treatment of diabetes mellitus-induced erectile dysfunction (DMED) has become increasingly challenging due to the limited efficacy of phosphodiesterase type 5 inhibitors (PDE5i).
Wenchao Xu, Peng Hu, Jiaxin Wang, Hongyang Jiang, Tao Wang, Jihong Liu, Hao Li   +6 more
doaj   +1 more source

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

, 2019
Tzu-Chi Chen, Jian‐Ying Chuang, Chiung-Yuan Ko, Tzu‐Jen Kao, Pei-Yu Yang, Chun-Hui Yu, Mingsheng Liu, Siou-Lian Hu, Yu-Ting Tsai, Hardy Chan, Wen‐Chang Chang, Tsung‐I Hsu   +11 more
openalex   +1 more source

FOXA2 Suppression by TRIM36 Exerts Anti‐Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4‐Regulated Ferroptosis [PDF]

, 2023
Xin Liu, Chunli Yan, Chunxiao Chang, Fansong Meng, Shen Wen-jie, Song Wang, Yi Zhang   +6 more
openalex   +1 more source

Lipid peroxidation and ferroptosis: The role of GSH and GPx4.

Free Radical Biology & Medicine, 2020
F. Ursini, M. Maiorino
semanticscholar   +1 more source

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc

Cellular and Molecular Life Sciences
Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative disorders and imposes places heavy medical and economic burdens on individuals and society.
Chunwang Jia, Ziqian Xiang, Pengfei Zhang, Long Liu, Xuetao Zhu, Ruixuan Yu, Zhicheng Liu, Shaoyi Wang, Kaiwen Liu, Zihao Wang, Krasimir Vasilev, Shuanhu Zhou, Ziwen Geng, Xinyu Liu, Yunpeng Zhao, Yuan Gao, Lei Cheng, Yuhua Li   +17 more
semanticscholar   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source