Results 301 to 310 of about 40,571 (376)

Targeting BMAL1 reverse drug resistance of acute myeloid leukemia cells and promoting ferroptosis through HMGB1-GPX4 signaling pathway [PDF]

Hong Zheng, Ting Wu, Zhi Lin, Dan Wang, Jing Zhang, Ting Zeng, Leping Liu, Jie Shen, Mingyi Zhao, Jia‐Da Li, Minghua Yang   +10 more
openalex   +1 more source

Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis

Cell Proliferation, EarlyView.
Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley   +1 more source

Ferroptosis in Hypertriglyceridemic Acute Pancreatitis: Mechanisms and Therapeutic Implications. [PDF]

J Inflamm Res
Zou K, Liu W, Xia W, Zhao Y.
europepmc   +1 more source

C. sinensis inhibits the Nrf2, SLC7A11, and GPX4 activity of hepatocyte through the secretion of ESPs, promoting GSH depletion, iron overload, leading to lipid ROS accumulation, and facilitating ferroptosis.

Haoyang Zhang (1706815), Xiaocen Wang (4055518), Xu Zhang (49484), Yeting Ma (14498201), Penglin Bao (21464492), Yanhui Yu (7323035), Yuru Wang (846969), Pengtao Gong (4055521), Nan Zhang (46264), Soon-Ok Lee (18981051), Xin Li (51274), Jianhua Li (36075)   +11 more
openalex   +1 more source

Agrimoniin Alleviates Ferroptosis in Cold‐Stored DCD Liver Grafts Through Activation of the Nrf‐2 Pathway

Cell Proliferation, EarlyView.
Supplementing the liver preservation solution with agrimoniin protects donation after cardiac death (DCD) grafts by activating the Nrf‐2 pathway. This reduces ferroptosis, oxidative stress, and inflammation during cold storage, significantly improving graft viability.
Enqiang Chang, Xiaoting Liao, Guanghua Tao, Bijun Luo, Sheng He, Linghui Pan   +5 more
wiley   +1 more source

Research progress of ferroptosis in cervical cancer treatment. [PDF]

Ann Med
Wang F, Wang L, Bai Y.
europepmc   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Ferroptotic resistance involved in PTEN-loss prostate cancer progression. [PDF]

Discov Oncol
Jing Y, Xing D, Zhao Z, Wang X.
europepmc   +1 more source

Adjunctive Therapies in Periodontitis: Current Concepts and the Future

Journal of Periodontal Research, EarlyView.
This graphical abstract summarizes the translational pathway from preclinical research to clinical implementation of adjunctive therapies for periodontitis, highlighting key barriers, innovative therapeutic strategies, and emerging tools that aim to bridge experimental discoveries with patient care.
Rafael Scaf de Molon, Joao Paulo Steffens, Erica Dorigatti de Avila, Wim Teughels, Thomas E. Van Dyke   +4 more
wiley   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source