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Ferroptosis in ocular diseases: mechanisms, crosstalk with other cell death pathways, and therapeutic prospects. [PDF]
Front Med (Lausanne)Huang S +6 more
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GPX4: old lessons, new features
Biochemical Society Transactions, 2022GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development.
Thamara, Nishida Xavier da Silva +2 more
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Small-molecule allosteric inhibitors of GPX4
Cell Chemical Biology, 2022Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which revealed an unexpected allosteric site. We found that this site was involved in native regeneration of GPX4 under low glutathione conditions.
Hengrui Liu +7 more
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GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis
PROTEOMICS, 2019AbstractOxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation of cholesterol and phospholipids containing polyunsaturated fatty acyl chains can lead to lipid peroxidation, membrane damage, and cell death.
Giovanni C. Forcina, Scott J. Dixon
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Lipid peroxidation and ferroptosis: The role of GSH and GPx4
Free Radical Biology and Medicine, 2020Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO takes place in a scenario of altered homeostasis. FPT, differently from apoptosis, occurs in the absence of any known specific genetically encoded death pathway or specific agonist,
Ursini Fulvio, Maiorino Matilde
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2019
Glutathione peroxidase 4 (Gpx4) is a monomeric glutathione peroxidase with a unique ability to reduce hydroperoxide in complex lipids. Gpx4 is vital for development, and its function is also indispensable for many cell types of adult animal. Ferroptosis is an iron-dependent oxidative cell death. In ferroptosis, a high load of hydroperoxides in membrane
Paulina Mozolewska, Qitao Ran
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Glutathione peroxidase 4 (Gpx4) is a monomeric glutathione peroxidase with a unique ability to reduce hydroperoxide in complex lipids. Gpx4 is vital for development, and its function is also indispensable for many cell types of adult animal. Ferroptosis is an iron-dependent oxidative cell death. In ferroptosis, a high load of hydroperoxides in membrane
Paulina Mozolewska, Qitao Ran
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Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA
Biochemistry, 2021Glutathione peroxidase 4 (GPx4) serves as the only enzyme that protects membranes through the reduction of lipid hydroperoxides, preventing membrane oxidative damage and cell death through ferroptosis. Recently, GPx4 has gained attention as a therapeutic target for cancer through inhibition and as a target for inflammatory diseases through activation ...
Courtney L. Labrecque, Brian Fuglestad
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Research progress on GPX4 targeted compounds
European Journal of Medicinal ChemistryBlocking the System Xc-_ GSH_GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein ...
Bingru Li +8 more
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