Results 281 to 290 of about 33,929 (300)

A potent GPX4 degrader to induce ferroptosis in HT1080 cells

European Journal of Medicinal Chemistry
Glutathione peroxidase 4 (GPX4) is the most promising target for inducing ferroptosis. GPX4-targeting strategies primarily focus on inhibiting its activity or adjusting its cellular level. However, small inhibitors have limitations due to the covalent reactive alkyl chloride moiety, which could lead to poor selectivity and suboptimal pharmacokinetic ...
Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li   +9 more
openaire   +2 more sources

GPx4

2018
Matilde Maiorino, Antonella Roveri, Fulvio Ursini   +2 more
openaire   +1 more source

Istraživanje feroptoznog inhibitora GPx4

2015
Istraživanje feroptoznog inhibitora ...
openaire   +1 more source

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2023
Nan Ma, Guotao Lu, Weiqin Li
exaly  

xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers

Antioxidants, 2021
Namgyu Lee, Anne E Carlisle, Mihir B Doshi   +2 more
exaly  

Interfering with GPX4 degradation

Nature Chemical Biology
Jing Li, Yuhan Zhou, Weimin Wang
openaire   +2 more sources

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Cell Reports, 2021
Travis S Johnson, Siyuan Zhang, Jie Zhang   +2 more
exaly  

Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy

EBioMedicine, 2021
Yaqian Xu, Xiaonan Sheng, Ziping Wu
exaly  

Unraveling Masked GPX4 Inhibitors

Synfacts, 2020
openaire   +1 more source

Plumbagin is a novel GPX4 protein degrader that induces apoptosis in hepatocellular carcinoma cells

Free Radical Biology and Medicine, 2023
Daolin Tang, Xin Chen
exaly