Results 271 to 280 of about 33,929 (300)

SMG9 drives ferroptosis by directly inhibiting GPX4 degradation

Biochemical and Biophysical Research Communications, 2021
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that plays an integral role in eliminating abnormal mRNA and corresponding proteins. It is unclear whether the NMD pathway is involved in regulating ferroptosis, which is a type of iron-dependent cell death mainly caused by the inhibition of the antioxidant SLC7A11-GPX4 axis.
Leng Han, Lulu Bai, Xue Fang, Jiao Liu, Rui Kang, Di Zhou, Daolin Tang, Enyong Dai   +7 more
openaire   +2 more sources

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Free Radical Biology and Medicine, 2020
Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO takes place in a scenario of altered homeostasis. FPT, differently from apoptosis, occurs in the absence of any known specific genetically encoded death pathway or specific agonist,
Ursini Fulvio, Maiorino Matilde
openaire   +3 more sources

Function and regulation of GPX4 in the development and progression of fibrotic disease

Journal of Cellular Physiology, 2022
AbstractFibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the development of fibrosis, including cytokines, hormones, and enzymes.
Zhaobing Li, Zigui Zhu, Yulu Liu, Yannan Liu, Hong Zhao   +4 more
openaire   +2 more sources

Research progress on GPX4 targeted compounds

European Journal of Medicinal Chemistry
Blocking the System Xc-_ GSH_GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein ...
Bingru Li, Keguang Cheng, Tzumei Wang, Xing Peng, Ping Xu, Guoquan Liu, Dong Xue, Ning Jiao, Chao Wang   +8 more
openaire   +2 more sources

Role of GPX4 in ferroptosis and its pharmacological implication

Free Radical Biology and Medicine, 2019
Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid peroxidation and metabolic constraints. Dependence on NADPH/H+, polyunsaturated fatty acid metabolism, and the mevalonate and glutaminolysis metabolic pathways have been implicated in this novel form of regulated necrotic cell death.
Seibt, T.M., Proneth, B., Conrad, M.
openaire   +3 more sources

Redox homeostasis maintained by GPX4 facilitates STING activation

Nature Immunology, 2020
Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumors. Redox homeostasis is the balance of oxidative and reducing reactions present in all living systems. Yet, how the intracellular redox state controls STING activation is unclear.
Mutian Jia, Danhui Qin, Chunyuan Zhao, Li Chai, Zhongxia Yu, Wenwen Wang, Li Tong, Lin Lv, Yuanyuan Wang, Jan Rehwinkel, Jinming Yu, Wei Zhao   +11 more
openaire   +2 more sources

Targeting GPX4 palmitoylation to boost antitumor immunity

Trends in Cancer
Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhancing ferroptosis resistance.
Daehee Hwang, Whitney S. Henry
openaire   +2 more sources

An overview of GPX4-targeting TPDs for cancer therapy

Bioorganic & Medicinal Chemistry
Ferroptosis is a newly identified form of regulated, non-apoptotic cell death caused by iron-dependent phospholipid peroxidation. Glutathione peroxidase 4 (GPX4) inactivation-induced ferroptosis is an efficient antitumor treatment. Currently, several GPX4 inhibitors have been identified.
Xiaojuan, Yang, Liqiang, Wu, Shaohong, Xu   +2 more
openaire   +2 more sources

Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges

Trends in Pharmacological Sciences
Selenoprotein glutathione peroxidase 4 (GPX4) serves as a crucial suppressor of oxidative stress-induced ferroptosis, making it an attractive target for disease therapy. Here, we discuss recent strategies and challenges associated with targeting GPX4 through covalent inhibitors, proteolysis targeting chimera (PROTAC) degraders, and cell-type-specific ...
Jiao Liu, Daolin Tang, Rui Kang
openaire   +2 more sources

A prospective therapeutic strategy: GPX4-targeted ferroptosis mediators

European Journal of Medicinal Chemistry
As a crucial regulator of oxidative homeostasis, seleno-protein glutathione peroxidase 4 (GPX4) represents the primary defense system against ferroptosis, making it a promising target with important clinical application prospects. From the discovery of covalent and allosteric sites in GPX4, substantial advancements in GPX4-targeted small molecules have
Jia-Yu Qian, Chao-Yuan Lou, Yi-Li Chen, Lie-Feng Ma, Wei Hou, Zha-Jun Zhan   +5 more
openaire   +2 more sources