Results 251 to 260 of about 33,929 (300)

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Mechanistic insights into a novel GPX4 inhibitor Compound AI-3p reversing cisplatin-resistance in ovarian cancer cells. [PDF]

J Ovarian Res
Wang B, Li D, Lai L, Lu Y, Wang TA, Song J, Wei P, Hou H, Zhang M, Wang C.   +9 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, Volume 20, Issue 5, Page 1161-1184, May 2026.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

miR-320a enhances radiosensitivity in non-small cell lung cancer by targeting RAD51 and modulating ferroptosis via GPX4. [PDF]

Sci Rep
Lv J, Zhang C, Ren X, Geng F, Li S, Wang Z, Quan X, Cheng Z, Wang R.   +8 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Targeting the GPX4-FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis-Associated Lung Injury. [PDF]

Adv Sci (Weinh)
Li Z, Liu C, Ma Z, Zheng D, Wang R, Yu Y, Chen G, Li C, Bu Y, Cao H, Zhang B.   +10 more
europepmc   +1 more source

The Mechanism of Ferroptosis and Blood-Brain Barrier Damage in Cerebrovascular Diseases. [PDF]

Biomedicines
Guo J, Yao C.
europepmc   +1 more source

Ginsenoside Rh4 Triggers Ferroptosis in Lung Cancer: Targeting <i>KEAP1</i>/<i>NRF2</i>/<i>HO-1</i> and Remodeling Gut Microbiota for Butyrate-Mediated <i>ATF3</i> Activation. [PDF]

Int J Mol Sci
Zhu Q, Xu W, Yang G, Gao Y, Zhao Y, Zhao Z, Kang Y, Li S, Zhao L.   +8 more
europepmc   +1 more source

RS-1: A Novel Hydrophobic Tagging GPX4 Degrader Inducing Ferroptosis and Suppressing Tumor Growth. [PDF]

ACS Omega
Feng Q, Zhang X, Liu Y, Li H, Liu R, Wang Y, Zhao S, Zhang X, Zhao M.   +8 more
europepmc   +1 more source

Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target. [PDF]

Mol Biomed
Yu S, Pang Z, Fang H, Liu C.
europepmc   +1 more source