Results 231 to 240 of about 26,946 (260)

Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges

Trends in Pharmacological Sciences
Selenoprotein glutathione peroxidase 4 (GPX4) serves as a crucial suppressor of oxidative stress-induced ferroptosis, making it an attractive target for disease therapy. Here, we discuss recent strategies and challenges associated with targeting GPX4 through covalent inhibitors, proteolysis targeting chimera (PROTAC) degraders, and cell-type-specific ...
Jiao Liu, Daolin Tang, Rui Kang
openaire   +2 more sources

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Autophagy, 2023
Daolin Tang, Daniel Klionsky, Guido Kroemer   +2 more
exaly  

Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression

EBioMedicine, 2022
Jingwei Zhang, Changqing Zhang, Guangyi Li   +2 more
exaly  

GPx4

2018
Matilde Maiorino, Antonella Roveri, Fulvio Ursini   +2 more
openaire   +1 more source

Interfering with GPX4 degradation

Nature Chemical Biology
Jing Li, Yuhan Zhou, Weimin Wang
openaire   +2 more sources

Istraživanje feroptoznog inhibitora GPx4

2015
Istraživanje feroptoznog inhibitora ...
openaire   +1 more source

Plumbagin is a novel GPX4 protein degrader that induces apoptosis in hepatocellular carcinoma cells

Free Radical Biology and Medicine, 2023
Daolin Tang, Jinbao Liu, Xin Chen
exaly  

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2023
Xiaowu Dong, Guotao Lu, Weiqin Li
exaly  

GPX4 methylation puts a brake on ferroptosis

Nature Cell Biology
Graeme I. Lancaster, Andrew J. Murphy
openaire   +2 more sources

MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4

Free Radical Research, 2021
Weihong Xu, Zhengquan Xu
exaly