Results 211 to 220 of about 26,946 (260)

Tumor cell-specific loss of GPX4 reprograms triacylglycerol metabolism to escape ferroptosis and impair antitumor immunity in non-small cell lung cancer. [PDF]

Protein Cell
Wang P, Zhang S, Chen X, Yang XD, Huang S, Yin H, Duan HY, Zhou F, Yu J, Zhong B, Lin D.   +10 more
europepmc   +1 more source

Heat stress induces ferroptosis in intramuscular preadipocytes of Hu sheep via activation of the TNF-α/NF-κB/GPX4 signaling axis. [PDF]

Food Chem (Oxf)
Wu S, Wei Y, Han Z, He H, Lu J, Liang Y, Tang L, Zou J, Zhang Y, Huang Y, Jiang Q.   +10 more
europepmc   +1 more source

Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review). [PDF]

Mol Med Rep
Ge L, Zhang T, Yu J, Xiao S, Zhou Y, Luo L.   +5 more
europepmc   +1 more source

Liuwei dihuang decoction attenuates intervertebral disc degeneration by inhibiting TRPA1-Mediated ferroptosis in endplate chondrocytes. [PDF]

Front Cell Dev Biol
Xu R, Yang Y, Xu P, Qin K, Li O, Wu T, Pan Y, Sheng C, Xie Z, Wu M, Wang J, Wang W, Ma T, Jin Z, Jiang D, Xia H, Li Y.   +16 more
europepmc   +1 more source

CB2 receptor agonist JWH133 attenuates hyperoxia-induced acute lung injury by inhibiting ferroptosis via GPX4 upregulation. [PDF]

Respir Res
Chu SJ, Liao WI, Pao HP, Wu SY, Tang SE.
europepmc   +1 more source

The Warburg Effect Suppresses Ferroptosis Through Activation of NADPH Sensing

Halsey C, Gajic N, Christie R, Martin J, Josephs-Spaulding J, Lam S, Ackermann T, Dunn K, Shokry E, Uribe AH, Irving J, Delft Fv, de Muyer F, Ntziachristos P, Voorde JV, Sumpton D, Tardito S, Brown A, Tait S.   +18 more
europepmc   +1 more source

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Small-molecule allosteric inhibitors of GPX4

Cell Chemical Biology, 2022
Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which revealed an unexpected allosteric site. We found that this site was involved in native regeneration of GPX4 under low glutathione conditions.
Brent Stockwell, Rajesh Kumar Soni, Hengrui Liu   +2 more
exaly   +3 more sources

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Proteomics, 2019
Abstract Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation of cholesterol and phospholipids containing polyunsaturated fatty acyl chains can lead to lipid peroxidation, membrane damage, and cell death.
Giovanni Forcina, Scott Dixon
exaly   +3 more sources

GPX4: old lessons, new features

Biochemical Society Transactions, 2022
GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development.
Thamara, Nishida Xavier da Silva, José Pedro, Friedmann Angeli, Irina, Ingold   +2 more
openaire   +2 more sources