Results 221 to 230 of about 33,929 (300)

Ferroptosis in Glioblastoma and Neuroblastoma: Molecular Mechanisms and Novel Therapeutic Strategies. [PDF]

Curr Issues Mol Biol
Liu Z, Ma Z, Yang K, Fan H.
europepmc   +1 more source

T-2 toxin és deoxinivalenol terhelés rövidtávú hatása a gpx4 gének expressziójára ponty fajban (Cyprinus carpio) [PDF]

, 2015
Balogh, Krisztián, Kovács, Balázs, Kövesi, Benjámin, Mézes, Miklós, Pelyhe, Csilla   +4 more
core  

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors. [PDF]

Genome Med
Tu C, Tan CW, Monkman J, Almeida AC, Antonio-Carreon G, Omer N, Hull G, Chung K, Mehdi AM, Salerno A, Vittorio O, Mayer A, Machado-Souza C, Jayabalan N, Toh YC, Hon HN, de Almeida Brehm Pinhatti F, Elifio-Esposito S, Nicholls W, de Noronha L, Kulasinghe A, Souza-Fonseca-Guimaraes F.   +21 more
europepmc   +1 more source

Rövid távú T-2 toxin és deoxinivalenol terhelés hatásai brojler csirkék glutation redox paramétereire [PDF]

, 2015
Balogh, Krisztián, Kovács, Balázs, Mézes, Miklós, Pelyhe, Csilla, Zándoki, Erika   +4 more
core  

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer. [PDF]

Cancer Metab
Mbah NE, Sutton D, Hong HS, Singhal R, Menjivar RE, Perricone MD, Giza H, Sajjakulnukit P, Myers AL, Nwosu ZC, Alektiar JM, Lin J, Long D, Andren AC, Zhang L, Crawford HC, Frankel TL, Pasca di Magliano M, Franchi L, Shah YM, Lyssiotis CA.   +20 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

LncRNA-PRLB drives ovarian cancer progression and chemoresistance by stabilizing GPX4 mRNA through the FUS-mediated suppression of ferroptosis. [PDF]

Front Med (Lausanne)
Jiang L, Pi J, Li N, Cao J, Zhao Y.
europepmc   +1 more source

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

Journal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng, Xiaoping Li, Jialuo Cai, Xinyu Chen, Zelin Xu, Yuntao Luo   +5 more
wiley   +1 more source