Results 261 to 270 of about 34,214 (293)

Research progress on GPX4 targeted compounds

European Journal of Medicinal Chemistry
Blocking the System Xc-_ GSH_GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein ...
Bingru Li, Keguang Cheng, Tzumei Wang, Xing Peng, Ping Xu, Guoquan Liu, Dong Xue, Ning Jiao, Chao Wang   +8 more
openaire   +2 more sources

Role of GPX4 in ferroptosis and its pharmacological implication

Free Radical Biology and Medicine, 2019
Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid peroxidation and metabolic constraints. Dependence on NADPH/H+, polyunsaturated fatty acid metabolism, and the mevalonate and glutaminolysis metabolic pathways have been implicated in this novel form of regulated necrotic cell death.
Seibt, T.M., Proneth, B., Conrad, M.
openaire   +3 more sources

Targeting GPX4 palmitoylation to boost antitumor immunity

Trends in Cancer
Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhancing ferroptosis resistance.
Daehee Hwang, Whitney S. Henry
openaire   +2 more sources

An overview of GPX4-targeting TPDs for cancer therapy

Bioorganic & Medicinal Chemistry
Ferroptosis is a newly identified form of regulated, non-apoptotic cell death caused by iron-dependent phospholipid peroxidation. Glutathione peroxidase 4 (GPX4) inactivation-induced ferroptosis is an efficient antitumor treatment. Currently, several GPX4 inhibitors have been identified.
Xiaojuan, Yang, Liqiang, Wu, Shaohong, Xu   +2 more
openaire   +2 more sources

Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges

Trends in Pharmacological Sciences
Selenoprotein glutathione peroxidase 4 (GPX4) serves as a crucial suppressor of oxidative stress-induced ferroptosis, making it an attractive target for disease therapy. Here, we discuss recent strategies and challenges associated with targeting GPX4 through covalent inhibitors, proteolysis targeting chimera (PROTAC) degraders, and cell-type-specific ...
Jiao Liu, Daolin Tang, Rui Kang
openaire   +2 more sources

Association of GPX4 rs713041 and rs4807542 polymorphisms and serum GPX4 levels in Chinese patients with systemic lupus erythematosus

Lupus
Objectives: To investigate the association of serum glutathione peroxidase 4 (GPX4) levels and GPX4 polymorphisms with systemic lupus erythematosus (SLE) and lupus nephritis (LN) in a Chinese population. Methods: This hospital-based ...
Xu Li, Lin Su, Xiang Li, Caifang Qin, Zhuo Qin, Yanan Sun, Xing Wei, Shuo Yang, Yongchao Liu, Ning Liu, Zhihong Zhang, Jiping Wu   +11 more
openaire   +1 more source

YLKTT, a potent biopeptide that ameliorates oxygen-glucose deprivation-induced neuronal cell ferroptosis by ACSL4/GPX4 and SLC7A11/GPX4 axis

Journal of Pharmacy and Pharmacology
Abstract Objectives Shuxuetong injection (SXT) treats cerebral ischemic injury by inhibiting apoptosis. However, the specific active ingredient responsible for this effect and its mechanism of action remain unclear.
Yujie Wu, Yansu Ji, Xin Jin, Guangjing Xu, Xiaoyu Wang, Saisai Song, Rui Li, Yuhan Wang, Rui Liu, Zheng Li   +9 more
openaire   +2 more sources

GPx4

2018
Matilde Maiorino, Antonella Roveri, Fulvio Ursini   +2 more
openaire   +1 more source

Istraživanje feroptoznog inhibitora GPx4

2015
Istraživanje feroptoznog inhibitora ...
openaire   +1 more source

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2023
Wangsen Cao, Yingying Lu, Xiaowu Dong
exaly