Results 71 to 80 of about 29,098 (325)

Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. [PDF]

, 2015
Maternal diet during pregnancy influences the later life reproductive potential of female offspring. We investigate the molecular mechanisms underlying the depletion of ovarian follicular reserve in young adult females following exposure to obesogenic ...
Aiken, Catherine E, Dearden, Laura, Ozanne, Susan E, Penfold, Naomi C, Tarry-Adkins, Jane L   +4 more
core   +2 more sources

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury

Journal of Integrative Neuroscience
Background: It has been reported that ferroptosis participates in the pathophysiological mechanism of spinal cord injury (SCI). Our preliminary experiments verified that dendrobium nobile polysaccharide (DNP) improved the behavioral function of SCI rats.
Jian Huang, Jianghong Luo, Ying Huang, Linghong Wang, Haibing Zhu, Zhengnan Li, Jianping Chen   +6 more
doaj   +1 more source

Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. [PDF]

, 2009
INTRODUCTION: Normal gene expression variation is thought to play a central role in inter-individual variation and susceptibility to disease. Regulatory polymorphisms in cis-acting elements result in the unequal expression of alleles.
Caldas, Carlos, Jones, Linda, Lee, Alvin JX, Maia, Ana-Teresa, O'Reilly, Martin, Ponder, Bruce AJ, Spiteri, Inmaculada   +6 more
core   +2 more sources

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Advanced Healthcare Materials, EarlyView.
Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti, Claudia Catarinicchia, Claudia Borri, Fulvio Ratto, Filippo Micheletti, Noemi Formica, Jessica Ruzzolini, Elena Frediani, Anastasia Chillà, Francesca Margheri, Mirko Severi, Rita Traversi, Patrizia Nardini, Daniele Guasti, Mario Del Rosso, Tommaso Del Rosso, Lisa Giovanelli, Cinzia Talamonti, Monica Mangoni, Isacco Desideri, Silvia Burchielli, Fabiola Pajar, Gabriella Fibbi, Anna Laurenzana   +26 more
wiley   +1 more source

Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast

Exploration of Medicine
Aim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
doaj   +1 more source

The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression

Redox Biology
Ferroptosis, a form of oxidative cell death mediated by lipid peroxidation, is strictly regulated by glutathione peroxidase 4 (GPX4). Knockout of Gpx4 results in embryonic lethality, highlighting its essential role in development. In vitro, mouse embryonic stem cells (mESCs), which represent the naïve pluripotent state, require β-mercaptoethanol (bME ...
Seokwoo Park, Mihn Jeong Park, Eun-Ji Kwon, Ji-Young Oh, Yeon-Joon Chu, Han Sun Kim, Sunghyouk Park, Tae Ha Kim, Sung Won Kwon, Yon Su Kim, Hyuk-Jin Cha   +10 more
openaire   +3 more sources

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

A systems biology approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells. [PDF]

, 2012
Nonalcoholic fatty liver disease (NAFLD) comprises a broad spectrum of disease states ranging from simple steatosis to nonalcoholic steatohepatitis (NASH).
Andriani eDaskalaki, Christian eRegenbrecht, Christoph eWierling, Frauke eHenjes, Hans eLehrach, Hans eLehrach, Hans eWesterhoff, Hans eWesterhoff, Hans eWesterhoff, Hans eWesterhoff, Ivano eBertini, James eAdjaye, James eAdjaye, Justyna eJozefczuk, Karl eKashofer, Kurt eZatloukal, Paola eTurano, Ramesh eUmmanni, Ramesh eUmmanni, Samrina eRehman, Suzanne eGeenen, Ulrike eKorf, Wasco eWruck   +22 more
core   +21 more sources

The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells

Cell Death Discovery, 2022
Ferroptosis is a caspase-independent form of regulated cell death strongly linked to the accumulation of reactive lipid hydroperoxides. Lipid hydroperoxides are neutralized in cells by glutathione peroxidase 4 (GPX4) and inhibitors of GPX4 are potent ...
Tanu Singh, Alexander Beatty, Jeffrey R. Peterson   +2 more
doaj   +1 more source