Results 101 to 110 of about 3,790,217 (289)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
AtmosphereAir quality assessments often require source apportioning of the air pollutants observed at the receptor site. Conventional source apportionment models are subject to high uncertainties due to the lack of accurate emission profiles of all the ...
Nima Afshar-Mohajer, Mirella Shaban
doaj +1 more source
Function Analysis of the Euclidean Distance between Probability Distributions
Entropy, 2018 Minimization of the Euclidean distance between output distribution and Dirac delta functions as a performance criterion is known to match the distribution of system output with delta functions.
Namyong Kim
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The Adjoint Method Formulation for an Inverse Problem in the Generalized Black-Scholes Model [PDF]
Journal of Systemics, Cybernetics and Informatics, 2006 A general framework is developed to treat optimal control problems for a generalized Black-Scholes model, which is used for option pricing. The volatility function is retrieved from a set of market observations.
PIERRE NGNEPIEBA
doaj
Gradient Regularized Natural Gradients
Gradient regularization (GR) has been shown to improve the generalizability of trained models. While Natural Gradient Descent has been shown to accelerate optimization in the initial phase of training, little attention has been paid to how the training dynamics of second-order optimizers can benefit from GR.
Dash, Satya Prakash; id_orcid 0009-0000-4822-823X +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Response: Alternative approaches for systematic review
Global Epidemiology, 2022 Julie E. Goodman +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source