Results 51 to 60 of about 3,790,217 (289)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Geological expediency for inclusion of the “easy” methods complex into the geological exploration for oil and gas

open access: yesGeoresursy, 2017
The article presents a triad of “easy” field methods for geological exploration of subsoil areas in the exploration and prospecting-evaluation stages of geological exploration for oil and gas.
D.M. Trofimov   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The accelerated integration of artificial intelligence systems and its potential to expand the vulnerability of the critical infrastructure [PDF]

open access: yesRevista Română de Informatică și Automatică
As artificial intelligence (AI) is becoming increasingly integrated into critical infrastructures, it brings about both transformative benefits and unprecedented risks. AI has the potential to revolutionize the efficiency, reliability, and responsiveness
Luca SAMBUCCI, Elena-Anca PARASCHIV
doaj   +1 more source

Autologous Gradient Formation under Differential Interstitial Fluid Flow Environments

open access: yesBiophysica, 2022
Fluid flow and chemokine gradients play a large part in not only regulating homeostatic processes in the brain, but also in pathologic conditions by directing cell migration.
Caleb A. Stine, Jennifer M. Munson
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Accumulated Gradient Normalization [PDF]

open access: yes, 2017
This work addresses the instability in asynchronous data parallel optimization. It does so by introducing a novel distributed optimizer which is able to efficiently optimize a centralized model under communication constraints. The optimizer achieves this
Hermans, Joeri   +2 more
core   +1 more source

Gradient-limited surfaces

open access: yes, 2002
A simple scenario of the formation of geological landscapes is suggested and the respective lattice model is derived. Numerical analysis shows that the arising non-Gaussian surfaces are characterized by the scale-dependent Hurst exponent, which varies ...
B. B. Mandelbrot   +8 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Multi-gradient fluids

open access: yes, 2018
An internal energy function of the mass density, the volumetric entropy and their gradients at n-order generates the representation of multi-gradient fluids. Thanks to Hamilton's principle, we obtain a thermodynamical form of the equation of motion which
Gouin, Henri
core   +3 more sources

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