Results 61 to 70 of about 3,790,217 (289)
Formation of thebicoidmorphogen gradient: an mRNA gradient dictates the protein gradient [PDF]
Development, 2009 The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole.
Spirov, A +5 more
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Adaptive Restart of the Optimized Gradient Method for Convex Optimization
, 2017 First-order methods with momentum such as Nesterov's fast gradient method are very useful for convex optimization problems, but can exhibit undesirable oscillations yielding slow convergence rates for some applications.
Fessler, Jeffrey A., Kim, Donghwan
core +1 more source
CoRR, 2016 Gradients have been used to quantify feature importance in machine learning models. Unfortunately, in nonlinear deep networks, not only individual neurons but also the whole network can saturate, and as a result an important input feature can have a tiny gradient.
Mukund Sundararajan +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Burgers Turbulence with Large-scale Forcing
, 1998 Burgers turbulence supported by white-in-time random forcing at low wavenumbers is studied analytically and by computer simulation. It is concluded that the probability density Q of velocity gradient displays four asymptotic regimes at very large ...
Goto, Toshiyuki +3 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Alternating gradient photodetector [PDF]
, 1989 A far infrared (FIR) range responsive photodetector is disclosed. There is a substrate of degenerate germanium. A plurality of alternating impurity-band and high resistivity layers of germanium are disposed on the substrate. The impurity-band layers have
Maserjian, Joseph, Overhauser, Albert W.
core +1 more source
Journal of Differential Equations, 1998 The purpose of this paper is to contribute to the theory of existence of solutions to ordinary differential equations in \(\mathbb{R}^n\), when the right hand side of the equation is not necessarily continuous. More precisely the authors study existence and uniqueness of solutions for the equation \(x'= \nabla u(x)\) when \(u\) is not necessarily ...
CELLINA, ARRIGO, Vornicescu, M.
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source