Results 91 to 100 of about 3,311,038 (365)

Strain-gradient elasticity and gradient-dependent plasticity with hierarchical refinement of NURBS [PDF]

Finite Elements in Analysis and Design, 2019
Higher-order strain-gradient models are relevant for engineering materials which exhibit size-dependent behaviour as observed from experiments. Typically, this class of models incorporate a length scale - related to micro-mechanical material properties - to capture size effects, remove stress singularities, or regularise an ill-posed boundary value ...
Kolo, I., Chen, L., de Borst, R.
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Torsional prestrain gradient and size dependence of initial yield for <100> Cu-Mn single crystals in tension

Journal of the Mechanical Behavior of Materials, 2012
The effect of torsional prestrain gradient on the size dependence of initial yielding during subsequent tension of Cu-Mn single crystals is investigated experimentally.
Eleftheriadis Iordanis, Neuhäuser Hartmut, Aifantis Elias C.   +2 more
doaj   +1 more source

Impurity transport in trapped electron mode driven turbulence

, 2013
Trapped electron mode turbulence is studied by gyrokinetic simulations with the GYRO code and an analytical model including the effect of a poloidally varying electrostatic potential. Its impact on radial transport of high-Z trace impurities close to the
Fülöp, T., Mollén, A., Moradi, S., Pusztai, I.   +3 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Numerical Study of the Lowest Energy Configurations for Global String-Antistring Pairs

, 1992
We investigate the lowest energy configurations for string - antistring pairs at fixed separations by numerically minimizing the energy. We show that for separations smaller than a critical value, a region of false vacuum develops in the middle due to ...
A. M. Srivastava, A. M. Srivastava, Ajit Mohan Srivastava, C. Rosenzweig, E. P. S. Shellard, F. A. Bais, M. Alford, M. B. Einhorn, T. W. B. Kibble, V. V. Khoze   +9 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Existence and Multiplicity Results for Degenerate Elliptic Equations with Dependence on the Gradient

Boundary Value Problems, 2007
We study the existence of positive solutions for a class of degenerate nonlinear elliptic equations with gradient dependence. For this purpose, we combine a blowup argument, the strong maximum principle, and Liouville-type theorems to obtain a ...
Sebastian Lorca, Leonelo Iturriaga
doaj   +2 more sources

Inter-ELM pedestal turbulence dynamics dependence on q95 and temperature gradient

Nuclear Fusion
A series of dedicated experiments from the DIII-D tokamak provide spatially and temporally resolved measurements of electron density and temperature, and multiscale and multichannel fluctuations over a wide range of conditions.
Z. Yan, G.R. McKee, J. Xia, X. Jian, R. Groebner, T. Rhodes, K. Barada, S. Haskey, J. Chen, S. Banerjee, F. Laggner, the DIII-D Team   +11 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source