Results 91 to 100 of about 3,278,211 (362)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Torsional prestrain gradient and size dependence of initial yield for <100> Cu-Mn single crystals in tension

Journal of the Mechanical Behavior of Materials, 2012
The effect of torsional prestrain gradient on the size dependence of initial yielding during subsequent tension of Cu-Mn single crystals is investigated experimentally.
Eleftheriadis Iordanis, Neuhäuser Hartmut, Aifantis Elias C.   +2 more
doaj   +1 more source

Numerical Study of the Lowest Energy Configurations for Global String-Antistring Pairs

, 1992
We investigate the lowest energy configurations for string - antistring pairs at fixed separations by numerically minimizing the energy. We show that for separations smaller than a critical value, a region of false vacuum develops in the middle due to ...
A. M. Srivastava, A. M. Srivastava, Ajit Mohan Srivastava, C. Rosenzweig, E. P. S. Shellard, F. A. Bais, M. Alford, M. B. Einhorn, T. W. B. Kibble, V. V. Khoze   +9 more
core   +2 more sources

Strain-gradient elasticity and gradient-dependent plasticity with hierarchical refinement of NURBS [PDF]

Finite Elements in Analysis and Design, 2019
Higher-order strain-gradient models are relevant for engineering materials which exhibit size-dependent behaviour as observed from experiments. Typically, this class of models incorporate a length scale - related to micro-mechanical material properties - to capture size effects, remove stress singularities, or regularise an ill-posed boundary value ...
Kolo, I., Chen, L., de Borst, R.
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Existence and Multiplicity Results for Degenerate Elliptic Equations with Dependence on the Gradient

Boundary Value Problems, 2007
We study the existence of positive solutions for a class of degenerate nonlinear elliptic equations with gradient dependence. For this purpose, we combine a blowup argument, the strong maximum principle, and Liouville-type theorems to obtain a ...
Sebastian Lorca, Leonelo Iturriaga
doaj   +2 more sources

Thermoelectric spin diffusion in a ferromagnetic metal

, 2009
We present a semiclassical theory of spin-diffusion in a ferromagnetic metal subject to a temperature gradient. Spin-flip scattering can generate pure thermal spin currents by short-circuiting spin channels while suppressing spin accumulations.
Ashcroft, Boukai, Gerrit E.W. Bauer, Giazotto, Gravier, Hatami, Hatami, Hershfield, Hochbaum, Moosa Hatami, Ono, Saburo Takahashi, Sadamichi Maekawa, Sales, Shimada, Tsyplyatyev, Uchida   +16 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Two-Dimensional turbulence in the inverse cascade range

, 1999
Numerical and physical experiments on the forced two-dimensional Navier-Stokes equations show that transverse velocity differences are described by ``normal'' Kolmogorov scaling $ \propto r^{2n/3}$ and obey a gaussian statistics.
Yakhot, Victor
core   +1 more source

Calcium Gradient‐Dependent and Calcium Gradient‐Independent Phosphorylation of Sarcoplasmic Reticulum by Orthophosphate [PDF]

European Journal of Biochemistry, 1978
Phosphorylation of the calcium‐transport ATPase of skeletal muscle sarcoplasmic reticulum by inorganic phosphate was investigated in the presence or absence of a calcium gradient. The maximum phosphoprotein formation in the presence of a calcium gradient at 20 °C and pH 7.0 is approximately 4 nmol/mg sarcoplasmic reticulum protein, but only between 2.4
C, Punzengruber, R, Prager, N, Kolassa, F, Winkler, J, Suko   +4 more
openaire   +2 more sources