Results 101 to 110 of about 3,188,796 (338)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Time and energy dependence of the cosmic ray gradient in the outer heliosphere [PDF]

, 1985
Pioneers 10 and 11, now 35 and 18 AU from the Sun, continue to extend our knowledge of the spatial dependence of cosmic ray intensities in the heliosphere.
Axford, I., Fillius, W., Wood, D.
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Torque-operated gradient-index axicon

, 2013
We describe a gradient-index axicon based on twisting of crystals. We demonstrate that the focal length of the axicon can be efficiently operated by the torsion moment.
Skab, Ihor, Smyk, Mykola, Vasylkiv, Yurij, Vlokh, Rostyslav   +3 more
core   +1 more source

Semilinear elliptic equations with dependence on the gradient

Electronic Journal of Differential Equations, 2012
In this article we consider elliptic equations whose nonlinear term depends on the gradient of the unknown. We assume that the nonlinearity has a asymptotically linear growth at zero and at infinity with respect to the second variable.
Guanggang Liu, Shaoyun Shi, Yucheng Wei
doaj  

Data-Dependent Stability of Stochastic Gradient Descent

, 2017
We establish a data-dependent notion of algorithmic stability for Stochastic Gradient Descent (SGD), and employ it to develop novel generalization bounds. This is in contrast to previous distribution-free algorithmic stability results for SGD which depend on the worst-case constants.
Kuzborskij, Ilja, Lampert, Christoph
openaire   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Pomeranchuk effect and spin-gradient cooling of Bose-Bose mixtures in an optical lattice

, 2012
We theoretically investigate finite-temperature thermodynamics and demagnetization cooling of two-component Bose-Bose mixtures in a cubic optical lattice, by using bosonic dynamical mean field theory (BDMFT).
A. Auerbach, Liang He, M. Reza Bakhtiari, T. Ho, Walter Hofstetter, Yongqiang Li   +5 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

FARADAY MAGNETOMETER WITH SHERIC POLE PIECES: IDENTIFICATION ZONE WITH A STABLE FORCE FACTOR

Российский технологический журнал, 2017
Basic principles and approaches in generation of devices for realization Faraday method are evaluated (for learning magnetic susceptibility of samples). It is noticed that problem exists - it is difficult to identify an operating area to coordinate here ...
A. V. Sandulyak, A. A. Sandulyak, M. N. Polismakova, D. O. Kiselev, D. A. Sandulyak   +4 more
doaj   +1 more source