Results 101 to 110 of about 3,703,082 (328)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Numerical Study of the Lowest Energy Configurations for Global String-Antistring Pairs

, 1992
We investigate the lowest energy configurations for string - antistring pairs at fixed separations by numerically minimizing the energy. We show that for separations smaller than a critical value, a region of false vacuum develops in the middle due to ...
A. M. Srivastava, A. M. Srivastava, Ajit Mohan Srivastava, C. Rosenzweig, E. P. S. Shellard, F. A. Bais, M. Alford, M. B. Einhorn, T. W. B. Kibble, V. V. Khoze   +9 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Semilinear elliptic equations with dependence on the gradient

Electronic Journal of Differential Equations, 2012
In this article we consider elliptic equations whose nonlinear term depends on the gradient of the unknown. We assume that the nonlinearity has a asymptotically linear growth at zero and at infinity with respect to the second variable.
Guanggang Liu, Shaoyun Shi, Yucheng Wei
doaj  

Two-Dimensional turbulence in the inverse cascade range

, 1999
Numerical and physical experiments on the forced two-dimensional Navier-Stokes equations show that transverse velocity differences are described by ``normal'' Kolmogorov scaling $ \propto r^{2n/3}$ and obey a gaussian statistics.
Yakhot, Victor
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

FARADAY MAGNETOMETER WITH SHERIC POLE PIECES: IDENTIFICATION ZONE WITH A STABLE FORCE FACTOR

Российский технологический журнал, 2017
Basic principles and approaches in generation of devices for realization Faraday method are evaluated (for learning magnetic susceptibility of samples). It is noticed that problem exists - it is difficult to identify an operating area to coordinate here ...
A. V. Sandulyak, A. A. Sandulyak, M. N. Polismakova, D. O. Kiselev, D. A. Sandulyak   +4 more
doaj   +1 more source

Exact scaling exponents in Korn and Korn-type inequalities for cylindrical shells [PDF]

, 2013
Understanding asymptotics of gradient components in relation to the symmetrized gradient is im- portant for the analysis of buckling of slender structures.
Grabovsky, Yury, Harutyunyan, Davit
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source