Results 71 to 80 of about 2,575,606 (330)
Nihon Kikai Gakkai ronbunshuShape design optimization of 3-dimensional solid structures must satisfy two key objectives: high mechanical performance and light weight. For machines in motion, time-response problems in design optimization are crucial for machine life and reliability,
Haruki IGAWA, Jin-Xing SHI
doaj +1 more source
One method for minimization a convex Lipschitz-continuous function of two variables on a fixed square [PDF]
Компьютерные исследования и моделирование, 2019 In the article we have obtained some estimates of the rate of convergence for the recently proposed by Yu. E.Nesterov method of minimization of a convex Lipschitz-continuous function of two variables on a square with a fixed side.
Dmitry Arkad'evich Pasechnyuk +1 more
doaj +1 more source
Preconditioned Bi-Conjugate Gradient Method for Radiative Transfer in Spherical Media
, 2009 A robust numerical method called the Preconditioned Bi-Conjugate Gradient (Pre-BiCG)method is proposed for the solution of radiative transfer equation in spherical geometry.A variant of this method called Stabilized Preconditioned Bi-Conjugate Gradient ...
Asensio Ramos +24 more
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Three-Dimensional Smoothed Particle Hydrodynamics Method for Simulating Free Surface Flows [PDF]
, 2013 In this paper, we applied an improved Smoothing Particle Hydrodynamics (SPH) method by using gradient kernel renormalization in three-dimensional cases. The purpose of gradient kernel renormalization is to improve the accuracy of numerical simulation by ...
Naa, Christian Fredy, Prayogo, Rizal Dwi
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
A Numerical Model to Estimate the Soil Thermal Conductivity Using Field Experimental Data
Applied Sciences, 2019 Soil thermal conductivity is an important parameter for understanding soil heat transfer. It is difficult to measure in situ with available instruments.
Leugim Corteze Romio +4 more
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ADADELTA: An Adaptive Learning Rate Method [PDF]
, 2012 We present a novel per-dimension learning rate method for gradient descent called ADADELTA. The method dynamically adapts over time using only first order information and has minimal computational overhead beyond vanilla stochastic gradient descent.
Zeiler, Matthew D.
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source