Results 51 to 60 of about 1,616,723 (373)

Interannual variation in season length is linked to strong co-gradient plasticity of phenology in a montane annual plant.

New Phytologist, 2019
Species are commonly distributed along latitudinal and elevational gradients of growing season length to which they might respond via phenotypic plasticity and / or adaptive genetic differentiation.
David J. Ensing, C. Eckert
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Localization Analysis of an Energy-Based Fourth-Order Gradient Plasticity Model

, 2015
The purpose of this paper is to provide analytical and numerical solutions of the formation and evolution of the localized plastic zone in a uniaxially loaded bar with variable cross-sectional area.
Jirásek, Milan, Rokoš, Ondřej, Zeman, Jan   +2 more
core   +1 more source

Uniform materials and the multiplicative decomposition of the deformation gradient in finite elasto-plasticity [PDF]

, 2008
In this work we analyze the relation between the multiplicative decomposition $\mathbf F=\mathbf F^{e}\mathbf F^{p}$ of the deformation gradient as a product of the elastic and plastic factors and the theory of uniform materials.
Bilby B., Cartan E., Ciancio V., Ciancio V., Lee E., Sedov L., Sidoroff F.   +6 more
core   +3 more sources

Gradient Plasticity for Single Crystals [PDF]

PAMM, 2010
AbstractThe kinematic relationship between classical single crystal kinematics and geometrically necessary dislocations will be clarified by a demonstrative example. The starting point for the dynamics is the contribution of geometrically necessary dislocations to the free energy, which leads to a kinematic hardening law. A simple two‐dimensional shear
Wulfinghoff, S., Böhlke, T.
openaire   +2 more sources

A fourth-order gauge-invariant gradient plasticity model for polycrystals based on Kröner’s incompatibility tensor [PDF]

Mathematics and mechanics of solids, 2017
In this paper we derive a novel fourth-order gauge-invariant phenomenological model of infinitesimal rate-independent gradient plasticity with isotropic hardening and Kröner’s incompatibility tensor inc ( ε p ) : = Curl [ ( Curl ε p ) T ] , where ε p is ...
F. Ebobisse, P. Neff
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modeling the hall-petch effect with a gradient crystal plasticity theory including a grain boundary yield criterion [PDF]

, 2013
. A strain gradient crystal plasticity theory including the gradient of the equiv- alent plastic strain ∇γeq is discussed. A grain boundary yield condition is proposed in order to account for the influence of the grain boundaries ...
Bayerschen, Eric, Böhlke, Thomas, Wulfinghoff, Stephan   +2 more
core  

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Questioning size effects as predicted by strain gradient plasticity

Journal of the Mechanical Behavior of Materials, 2013
The analytical solution of the elastic-plastic response of a two-phase laminate microstructure subjected to periodic simple shear loading conditions is derived considering strain gradient and micromorphic plasticity models successively. One phase remains
Forest Samuel
doaj   +1 more source