Results 71 to 80 of about 1,849,278 (326)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Anterior-posterior gradient of plasticity in primate prefrontal cortex
Nature Communications, 2018 Studies of the functional organization of the prefrontal cortex have produced contradicting results depending on the task used. Here, Riley and colleagues demonstrate that prefrontal areas are specialized across the anterior posterior axis and that the ...
Mitchell R. Riley +3 more
doaj +1 more source
Strain gradient plasticity modeling of hydrogen diffusion to the crack tip [PDF]
, 2016 In this work hydrogen diffusion towards the fracture process zone is examined accounting for local hardening due to geometrically necessary dislocations (GNDs) by means of strain gradient plasticity (SGP). Finite element computations are performed within
E. Mart'inez-Paneda +3 more
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A gradient plasticity model for the simulation of shear localization
Advances in Mechanical Engineering, 2017 The numerical simulation of shear localization under high strain rates can be modeled by a system of four partial differential equations including conservation of momentum, conservation of energy, elastic, and inelastic constitutive relations.
Xiaocui Chen, Chengbin Du
doaj +1 more source
On fracture in finite strain gradient plasticity [PDF]
, 2016 A general framework for damage and fracture assessment including the effect of strain gradients is provided. Both mechanism-based and phenomenological strain gradient plasticity (SGP) theories are implemented numerically using finite deformation theory ...
E. Mart'inez-Paneda, C. F. Niordson
semanticscholar +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Korn's second inequality and geometric rigidity with mixed growth conditions
, 2012 Geometric rigidity states that a gradient field which is $L^p$-close to the set of proper rotations is necessarily $L^p$-close to a fixed rotation, and is one key estimate in nonlinear elasticity.
A Korn +21 more
core +1 more source
Journal of the mechanics and physics of solids, 2021 The ability of softening strain gradient plasticity to simulate intragranular plastic slip localization modes called slip and kink bands, at is investigated at incipient plasticity.
Aldo Marano, L. Gélébart, S. Forest
semanticscholar +1 more source